Normal tissue toxicity markedly reduces the therapeutic index of genotoxic anticancer agents, including ionizing radiation. Countermeasures against tissue damage caused by radiation are limited by their potential to also protect malignant cells and tissues. Here, we tested a panel of signal transduction modifiers for selective radioprotection of normal but not tumor tissues. These included thre...

We usually think of a graph visually, i.e. we see vertices as points on a plane or in space, with edges as lines connecting them. When speci ed algebraically (e.g. by its adjacency matrix), the geometrical imagery is lost. Can we nd a natural embedding of a graph in the plane or in space given the adjacency matrix? This is the question for the lecture. It will turn out that such an embedding ca...

The authors investigated how expertise in motor skills that require fine postural control, such as gymnastics, influences postural regulation. Gymnasts and nongymnasts performed a postural stabilization task after anterior–posterior destabilization while looking at a target in front of them. The authors recorded and analyzed the center of pressure and the ankle, knee, and hip displacements. Gym...

BACKGROUND Multi-drug resistant tuberculosis (MDR-TB) is a major public health problem especially in developing countries. World Health Organization (WHO) recommends use of Xpert MTB/RIF assay to simultaneously detecting Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. The primary objective of this study was to determine the frequency of MDR-TB in patients suspected to have dru...

Acute kidney injury (AKI) induced by ischemia-reperfusion is a critical conundrum in many clinical settings. Here, this study aimed to determine whether and how RTA-408, a novel oleanane triterpenoid, could confer protection against renal ischemia-reperfusion injury (IRI) in male mice. Mice treated with RTA-408 undergoing unilateral ischemia followed by contralateral nephrectomy had improved re...

We present a new 408 MHz survey (B3.1) carried out with the " Croce del Nord " radiotelescope in Bologna. The survey coordinates limits are −2 • 00 ′ to +2 • 15 ′ in Dec. and 21h to 24h, 00h to 17h in R.A., equivalent to 0.388 sr. The B3.1 is complete to 0.15 Jy but many sources down to 0.1 Jy are included. Our aim was to select a new and complete sample of Ultra Steep Spectrum (USS) radio sour...

Viruses are ubiquitous components of the marine environment, frequently reaching concentrations of 107–108 viruses per milliliter of surface seawater. The majority of these viral particles are bacteriophages (phages). Although the oceans are probably the largest pool of bacteriophages on the planet, the evolutionary relationships of marine phages to phages from other environments are unknown. T...

For effective Customer Relationship Management (CRM), it is essential to have information on the potential value of customers. Based on the interplay between potential value and realized value, managers can devise customer specific strategies. In this article we introduce a model for predicting the potential value of a current customer. Furthermore, we discuss and apply different modeling strat...

Several approaches with reference to customer involvement in the product development process can be found in the research literature. The majority of studies, focusing primarily on customer involvement in the product or service development process, are based on research in the area of new product development. However, these studies did not describe which customers or groups of customers are sui...

A new HPLC-DAD method has been developed and validated for the simultaneous analysis of five flavonoids (rutin, quercitrin, quercetin, kaempferol, and isorahamnetin) in rat plasma. Sample pretreatment consisted of a liquid–liquid extraction. The five flavonoids was separated on a kromasil C18 column and recorded at 350 nm. The greatest resolution was achieved with methanol-0.1% formic acid grad...