The authors are not native speakers of Turkish
 
 purpose this literature review was to systematize data from studies the biological activity 1,2,4-triazole derivatives with substituents in positions 4 and 5. set task forming an idea current directions selection substitutions for based on research. As a result study, 75 sources were analyzed. This made it possible form further vector ...

Twelve new triazole derivatives of Phrymarolin were prepared from Phrymarolin I and the structures of all the derivatives were fully characterized by (1)H-NMR, (13)C-NMR and MS spectral data analyses. Larvicidal activities against 4rd instar larvae of Culex pipiens pallens of these Phrymarolin analogues were assayed. Although the triazole derivatives of Phrymarolin showed certain larvicidal act...

Heterocyclic compounds have paying strong attention interest. Many different derivatives have been prepared and possess various type useful pharmacological activities. A lot of work has been done on five member heterocyclic triazole ring system. Different pharmacological activities of triazole ring and its derivatives have been observed. Triazole derivatives possess a wide range of pharmacologi...

In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with h...

ABSTRACT By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by 19F-NMR and other spectroscopy. GRAPHICAL ABSTRACT

Abstract Despite the remarkable progress in diagnostic and antifungal drugs research in past 10 years ,still complexity of the characteristics of patients continue to make the management of fungal infection is a great challenge .1,2,4-triazole compounds not only offer an interesting chemistry but also their various derivatives possesses diverse chemotherapeutic activity. The recent literatures ...

About half of the drugs currently produced are chiral compounds, and about 90 % these compounds sold as racemates, consisting an equimolar mixture two enantiomers. Although they have same chemical structure, most optical isomers substances show marked differences in biological activity. It is known that presence a single asymmetric atom has become almost integral part advanced drug design. The ...

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazol...

Thiazolotriazole derivatives have a number of biological activities. Electrophilic intramolecular cyclization unsaturated alkyl 1,2,4-triazole under the action various electrophilic reagents (halogens, tetrahalides chalcogenides) is most effective and simple method synthesis thiazolotriazoles.
 It was previously reported that 3-metalylthio-4,5-diphenyl-1,2,4-triazole reacts with aryltellur...