Condensation of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one with different aromatic and heterocyclic aldehydes in dry toluene give schiff bases 3(a-g), which on reaction with thioglycolic acid and thiolactic acid in dry toluene give the corresponding 2,3-disubstituted-4-thiazolidinones 4(a-g) and 2,3-disubstituted-5-methyl-4thiazolidinones 5(a-g). The methylene carbon atom at the position ...

The aim of the work was to identify anti-inflammatory effect a newly synthesized drug from group 4-thiazolidinones. Thus, comparative study two agents conducted: Les6490 and non-steroidal nimesulide. This belongs drugs (NSAIDs), which have pronounced anti-inflammatory, analgesic antipyretic effects. Nimesulide highly selective inhibitors cyclooxygenase its isoenzymes (COX-2) is used for treatme...

In search of new erythromycin derivatives 3-O-[gamma-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives have been synthesized. The 3-hydroxy group was derivatised to a primary amine and subsequently the thiazolidinone nucleus was generated at the amino functionality through DCC mediated one-pot three-component reaction in good yields.

A N-methyl-2-pyrrolidonium hydrogensulfate [NMP][HSO4] bronsted acidic ionic liquid-promoted cyclocondensation-cyclization pathway has been established using one pot reaction of anilines, aldehydes and mercaptoacetic acid to give 4-thiazolidinone derivatives in good promising yields microwave irradiation. Applications for this protocol are easy workup, high yields, short times, variability func...

A series of novel thiazolidinones have been synthesized by reaction of various Schiff bases of coumarin with thioglycolic acid. The reaction of 4-hydroxy coumarin with POCl3 yielded 4chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with pphenylene diamine to yield 4-[(4-aminophenyl)amino]-2H-chromen-2-one.Various Schiff bases of coumarin were synthesized by co...