induced by toluene diisocyanate. Am Rev Respir Dis, 1987, 136, 36-42. 8. Boschcuo P, Fabbri LM, Zocca E. Milani OF, Pivirotto P, Dal Vecchio A, Plebani M, Mapp CB. Prednisone inhibits late asthmatic reactions and airway infli!Jllmation induced by toluene diisocyanate in seruitiz.ed subjects. J Allergy Clin lmmunol, 1987, 80, 261267. 9. Fabbri LM, Di Giaromo R. Dal Vecchio L, Zocca E, De Marzo N...

In recent years, occupational asthma has become the most frequent occupational lung disease in many countries. Reports and statements on the frequency of occupational asthma due to isocyanates are quite contradictory. In order to clarify the issue, a critical review of the medical literature of the past half century worldwide has been performed, with special emphasis on toluene diisocyanate (TD...

Over the last decade, the U.S. Environmental Protection Agency (EPA) has been developing, refining, and updating the National Toxics Inventory (NTI), a nationwide emissions inventory of 188 compounds and classes of compounds that are listed as hazardous air pollutants (HAPs) under the federal Clean Air Act. One of these compounds is 4, 4’-methylene diphenyl diisocyanate (MDI), which is widely u...

Aluminum aminoterephthalate MOF particulate materials (NH(2)-MIL-101(Al) and NH(2)-MIL-53(Al)), studied here as components of self-detoxifying surfaces, retained their reactivity following their covalent attachment to protective surfaces utilizing a newly developed strategy in which the MOF particles were deposited on a reactive adhesive composed of polyisobutylene/toluene diisocyanate (PIB/TDI...

PURPOSE OF REVIEW Diisocyanates are the leading cause of occupational asthma, the most commonly reported lung disease associated with the workplace. Clinical studies have implicated the immune system in the pathogenesis of occupational asthma, but ethical and moral issues prevent mechanistic investigations in humans. For this reason, the development and characterization of animal models are ger...

An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass spectrometry. Studied isocyanates were isophorone diisocyanat...

aqueous polyurethane dispersions (puds) have recently emerged as important alternatives to their solvent-based counterparts for various applications due to increasing health and environmental awareness (green chemistry). anionic polyester-polyurethane dispersions were synthesized by three steps. in the first step, macromonomer diisocyanate having carboxylic acid was prepared by isophorone diiso...

Pseudomonas mendocina KR1 grows on toluene as a sole carbon and energy source. A multicomponent oxygenase was partially purified from toluene-grown cells and separated into three protein components. The reconstituted enzyme system, in the presence of NADH and Fe2+, oxidized toluene to p-cresol as the first detectable product. Experiments with p-deutero-toluene led to the isolation of p-cresol w...