2-Substituted azetidin-3-ones can be prepared in good yields and enantioselectivities (up to 85% ee) by a one-pot procedure involving the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a wide range of electrophiles, including alkyl, allyl, and benzyl halides and carbonyl compounds, followed by hydrolysis using oxalic acid.

Copper(ii) tetrasulfophthalocyanine supported on three-dimensional nitrogen-doped graphene-based frameworks was synthesized and introduced as a bifunctional catalyst for selective aerobic oxidation of alkyl arenes and alcohols to the corresponding carbonyl compounds. The ease of catalyst separation, high turnover, low catalyst loading and recyclability could potentially render it applicable in ...

Different procedures for the syntheses of the title compounds were investigated. The best method for the preparation of the title compounds were the reaction of the readily available 2-formyL-1-methyl-5-nitroimidazole2- substituted-4-formylthiazoles with alkyl acetoacetate and alkyl aminocrotonate in boiling alcohol.

The 4-hydroxyacetophenone monooxygenase (HAPMO) from Pseudomonas fluorescens ACB catalyzes NADPH- and oxygen-dependent Baeyer-Villiger oxidation of 4-hydroxyacetophenone to the corresponding acetate ester. Using the purified enzyme from recombinant Escherichia coli, we found that a broad range of carbonylic compounds that are structurally more or less similar to 4-hydroxyacetophenone are also s...

In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their Ki values. A few alpha-methyl- or alpha, alpha-dimethylarachidonoylalkylamides were also examined. In the 20:4, n-6 series, the unsubstituted amide is inactive; N-monoal...

Abstract Regioselectivity of visible-light-induced transformations a range (hetero)aryl alkyl-substituted ketones bearing several competitive reactive sites ( ? -carbonyl, benzyl and aromatic ring) with N- bromosuccinimide (NBS) was studied under solvent-free reaction conditions (SFRC) in the absence inert-gas atmosphere, radical initiators catalysts. An 8-W energy-saving household lamp used fo...

With the aid of a chiral nickel catalyst, enantioselective γ- (and δ-) alkylations of carbonyl compounds can be achieved through the coupling of γ-haloamides with alkylboranes. In addition to primary alkyl nucleophiles, for the first time for an asymmetric cross-coupling of an unactivated alkyl electrophile, an arylmetal, a boronate ester, and a secondary (cyclopropyl) alkylmetal compound are s...

The known properties of alkyl and aryl derivatives of transition elements are reviewed, with particular attention to binary compounds of this type. Factors contributing to thermal stability of metal—carbon a-bonds are discussed and new contributions are presented dealing with: (1) chemistry of titanium(Iv) and titaniurn(n); (ii) metal—carbon bonds in N,N'-ethylenebis(salicylideneiminato) comple...