Postrhinal (POR) or perirhinal (PER) cortex damage impairs acquisition and expression of contextual fear, but the nature of the impairment remains unclear. This study used a contextual fear discrimination paradigm that biased subjects toward using a configural, rather than an elemental, strategy to distinguish between 2 contexts, I of which was paired with a mild footshock. Control rats discrim...

The Pharmacovigilance Centre Lareb received 621 reports of possible adverse drugs reactions on Diane-35® . Of all reports, 388 were received after media attention. Of the 309 reports of thromboembolic adverse drugs reactions, 18 cases were fatal. In 31 cases the thromboembolic adverse drugs reaction was initially not recognized as such. The analysis and the turmoil of the 'Diane affair' gave ri...

Three experiments examined the effects of perirhinal cortex lesions on rats' retrograde and anterograde memory for object-discriminations and water-maze place-memory problems. In Experiment 1, rats learned two object-discriminations - the first was learned 2 weeks before surgery and the second 24 h before surgery. Rats with perirhinal cortex lesions displayed mildly impaired retention of both o...