Heritage is an important part of the international tourism market. As with any resource, sustainable management practices are required to maintain the long-term value of heritage assets. It is claimed that sustainable heritage tourism provides quality experiences for the tourists while protecting the environment and improving the quality of life for local residents. Yet, irrespective of how tou...

Despite the wide use of personality in understanding human behavior, there is a lack of empirical research relating the commonly agreed personality measurement with travel personality or travel related activities. In fi lling the knowledge gap, this study aims at exploring the relationship between the Big Five Factors (BFF) of personality and travel personality. Using self-administered question...

We have recently shown that proteasome inhibitor PS-341 induces apoptosis in drug-resistant multiple myeloma (MM) cells, inhibits binding of MM cells in the bone marrow microenvironment, and inhibits cytokines mediating MM cell growth, survival, drug resistance, and migration in vitro. PS-341 also inhibits human MM cell growth and prolongs survival in a SCID mouse model. Importantly, PS-341 has...

Th ere is no doubt that customer satisfaction is an integral part of services marketing and holds an important place in terms of providing higher profi tability and repeat purchase behavior. Keeping this in mind, this study sets out to explore the satisfaction of tourists of diff erent nationalities at fi ve-star hotels in Antalya. A questionnaire was employed and administered to 2,907 visitors...

The high-resolution (2 + 1) resonance-enhanced multiphoton-ionization photoelectron spectroscopy (REMPI-PS) can be obtained by measuring the photoelectron intensity at a given kinetic energy and scanning the single π phase step position. In this paper, we further demonstrate that the high-resolution (2 + 1) REMPI-PS cannot be achieved at any measured position of the kinetic energy by this measu...

The anticancer activity of the boronic acid dipeptide proteasome inhibitor PS-341 was examined in vitro and in vivo. PS-341 was a potent cytotoxic agent toward MCF-7 human breast carcinoma cells in culture, producing an IC90 of 0.05 microM on 24 h of exposure to the drug. In the EMT-6 tumor cell survival assay, PS-341 was equally cytotoxic administered p.o. or by i.p. injection up to a dose of ...

The proteasome inhibitor PS-341 inhibits IkappaB degradation, prevents NF-kappaB activation, and induces apoptosis in several types of cancer cells, including chemoresistant multiple myeloma (MM) cells. PS-341 has marked clinical activity even in the setting of relapsed refractory MM. However, PS-341-induced apoptotic cascade(s) are not yet fully defined. By using gene expression profiling, we ...

Recent studies have shown that the transcription factor nuclear factor kappaB (NF-kappaB) regulates critical survival pathways in a variety of cancers, including human T-cell leukemia/lymphotrophic virus 1 (HTLV-1)-transformed CD4 T cells. The activation of NF-kappaB is controlled by proteasome-mediated degradation of the inhibitor of nuclear factor kappaBalpha (IkappaBalpha). We investigated t...

Because of the pivotal role the proteasome plays in apoptosis, inhibitors of this enzyme, such as PS-341, provide a great opportunity for exploring synergy between proteasome inhibition and other apoptosis-inducing agents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells. In overnight assays, combinations of PS-341 and TRAIL were mu...