BACKGROUND Petasin (Ze 339) was recently introduced on the market as a potent herbal antiallergic drug for treatment of respiratory allergies such as hay fever. Few clinical studies have been performed so far addressing the clinical effectiveness of Ze 339. OBJECTIVE To evaluate the antiallergic properties of Ze 339 using skin prick tests with different stimuli, such as codeine, histamine, me...

MicroRNAs (miRNAs) have been suggested to play a vital role in regulate tumor progression and invasion. However, the expression of miR-339-5p in colorectal cancer and its effects are not known. Here, we report that miR-339-5p is a tumor suppressor by regulating expression of PRL-1. In this study, we showed that downregulated miR-339-5p levels in colorectal cancer tissues and highly invasive CRC...

Recently, we have found that a number of microRNAs (miRNAs) and proteins are involved in the response to acupuncture therapy in hypertensive rats. Our bioinformatics study suggests an association between these miRNAs and proteins, which include miR-339 and sirtuin 2 (Sirt2). In this paper, we aimed to investigate whether Sirt2 was a direct target of miR-339 in neurons. In human SH-SY5Y cells, t...

INTRODUCTION Combination treatment with fingolimod (FTY720) plus pathogenic antigen is thought to prevent glucose-6-phosphate isomerase (GPI)325-339-induced arthritis progression by effective induction of immune tolerance. Here, we examined the efficacy of this combination treatment on remission maintenance. METHODS GPI325-339-induced arthritis mice were treated for 5 days with FTY720 (1.0 mg...

For the first time, the effect of mechanical clearing of a native ohia/koa (Metrosideros polymorpha)/(Acacia koa) forest has been determined on some Hawaiian birds. Counts conducted on Keauhou Ranch, Island of Hawaii, at 6-month intervals, from December 1977/January 1978 through June/July 1983, showed that species richness and bird abundance were lower in the mechanically cleared or treated plo...

Pulmonary artery hypertension (PAH) is a fatal disorder. Recent studies suggest that microRNA (miRNA) plays an important role in regulating proliferation of pulmonary artery smooth muscle cells (PASMC), which underlies the pathology of PAH However, the exact mechanism of action of miRNAs remains elusive. In this study, we found that miR-339 was highly expressed in the cardiovascular system and ...

Department of Animal, Wildlife and Grassland Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. Department of Hematology and Cell Biology, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. Department of Animal and Wildlife Sciences, University of Pretori...

Wystąpienie ostrego niedokrwienia kończyny (ALI, acute limb ischaemia) wiąże się ze znacznym ograniczeniem lub zatrzymaniem przepływu w tętnicach kończyny dolnej. Jedną z przyczyn ALI może być zatorowość (35–40%) sercopochodna w przebiegu np. migotania przedsionków lub zawału serca (80%). Objawy ostrego niedokrwienia kończyn dolnych zależą od liczby i średnicy naczyń, które uległy całkowitemu z...