CONTEXT Borderline personality disorder (BPD) is traditionally considered chronic and intractable. OBJECTIVE To compare the course of BPD's psychopathology and social function with that of other personality disorders and with major depressive disorder (MDD) over 10 years. DESIGN A collaborative study of treatment-seeking, 18- to 45-year-old patients followed up with standardized, reliable, ...

Pancreatic cancer (PC) is a highly lethal disease due to extensive metastatic lesions. Accumulating evidence suggests that miR-675-5p plays different roles in metastasis through the regulation of epithelial to mesenchymal (EMT) and the mesenchymal to epithelial transitions (MET) in different cancers. ZEB1 promotes the EMT process by controlling the expression of E-cadherin and may have a recipr...

This article presents the main features and objectives of the so-called «social mechanisms based explanation» or «analytical sociology». This perspective has gained quite considerable attention in contemporary debate, both for its theoretical novelty as well as for its empirical results. In the first part of the article I describe the key concepts, main scholars and institutional strengths of t...

The aim of this article is to describe the evolution of a very dynamic theory: the theory of intertemporal choice. I present the first economic thinking on intertemporal decision-making, and expose how it resulted in Samuelson’s famous discounted utility model; then I describe how and why discounted utility became the standard approach to intertemporal choice in economics through the alleged no...

Long non-coding RNAs (lncRNAs) play key roles in the progression and metastasis of some carcinomas. We previously showed that the expression of lncRNA H19 (H19) was higher in gastric cancer (GC) tissues than that in paired noncanerous tissues. However, the underlying mechanisms remain unclear. In this study, H19/miR-675 knockdown models in the MKN45 cell line and ectopic expression models in th...

As the social sciences deal with macrophenomena which are caused by individual human actions, they have to use a theory of human behaviour. They use basically three types of theory: the rational-utilitarian theory, the causalist theory which sees behaviour as caused by social, cultural or biological forces, and the «rational psychology» in Nisbet’s sense. The three theories are important in the...

Despite their distinct objects of study, the human behavioral sciences all include models of individual human behavior. Unity in the behavioral sciences requires that there be a common underlying model of individual human behavior, specialized and enriched to meet the particular needs of each discipline. Such unity does not exist, and cannot be easily attained, since the various disciplines hav...

This paper argues for a closer association between economics and sociology. The latter could benefit from the intellectual rigour of the former. Building a unified socio-economics requires an intellectual rapprochement between the sociologist conception of social interaction and a relaxed version of rational choice. Evolutionary game theory may provide

BACKGROUND Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types of cancer and miR-675 is reported to be embedded in H19's first exon. However, their function and specific mechanisms of action have not been fully elucidated. The aim of this study was to identify a novel lncRNA-microRNA-mRNA functional network in gastric cancer. METHOD...

Abnormal expression of miR-675 has been found in various human tumors. However, the expression pattern of miR-675 in prostate cancer patients and its clinical significance remain largely elusive. In the present study, we evaluated the expression status of miR-675 gene in 83 prostate cancer patients and 40 benign prostatic hyperplasia (BPH) cases using real-time quantitative PCR. The results rev...