Membrane transporter proteins may influence the sensitivity of cancer cells to anticancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breast cancer cell lines by measuring the absolute protein expression levels of multiple transporters and other membrane proteins and examining their co...

Tumor associated macrophages (TAMs) can modify the tumor microenvironment to create a pro-tumor niche. Manipulation of the TAM phenotype is a novel, potential therapeutic approach to engage anticancer immunity. siRNA is a molecular tool for knockdown of specific mRNAs that is tunable in both strength and duration. The use of siRNA to reprogram TAMs to adopt an immunogenic, anti-tumor phenotype ...

This document suggests an X.500 Directory Schema, or Naming Architecture, for use in the COSINE and Internet X.500 pilots. The schema is independent of any specific implementation. As well as indicating support for the standard object classes and attributes, a large number of generally useful object classes and attributes are also defined. An appendix to this document includes a machine process...

The Internet is rapidly becoming the communications infrastructure. With its advantages of speed, availability, and `different time, different place' mode of communication, it can be successfully harnessed to accomplish tasks that previously required face-to-face meetings. Such meetings can consume large travel budgets and staff time, and therefore alternative mechanisms that achieve the same r...