Three new (2-4) and one known (1) sphingolipid were identified in the MeOH extract of Bombycis Corpus 101A. Their structures were elucidated as (4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine (1), (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine (2), (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine (3), and (4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine (4) on the basis of ...

(2S,3S)-2,3-Butanediol ((2S,3S)-2,3-BD) is a potentially valuable liquid fuel and an excellent building block in asymmetric synthesis. In this study, cofactor engineering was applied to improve the efficiency of (2S,3S)-2,3-BD production and simplify the product purification. Two NADH regeneration enzymes, glucose dehydrogenase and formate dehydrogenase (FDH), were introduced into Escherichia c...

We prove the existence of a positive SOLA (Solutions Obtained as Limits Approximations) to following PDE involving fractional power Laplacian ( ? ? ) s u = 1 ? + ? 2 ? ? in ? , > 0 ? N ? . Here, is bounded domain ?N, s?(0,1), 2s<N, ?,??(0,1), 2s?=2N?N?2s critical Sobolev exponent and nonnegative Radon measure ?.

An orientation of a graph G is a mod(2s + 1)-orientation if under this orientation, the net out-degree at every vertex is congruent to zero mod(2s + 1). If for any function b : V (G) → Z2s+1 satisfying  v∈V (G) b(v) ≡ 0 (mod 2s + 1), G always has an orientation D such that the net out-degree at every vertex v is congruent to b(v) mod (2s + 1), then G is strongly Z2s+1-connected. In this paper,...

We consider the nonlocal Hénon-Gelfand–Liouville problem $$\begin{aligned} (-\Delta )^s u = |x|^a e^u\quad \mathrm {in}\quad \mathbb {R}^n, \end{aligned}$$ for every $$s\in (0,1)$$ , $$a>0$$ and $$n>2s$$ . prove a monotonicity formula solutions of above equation using rescaling arguments. apply this together with blow-down analysis arguments technical integral estimates to establish non-existen...

Three stereoisomeric inhibitors of Pin1: (2R,5S)-, (2S,5R)- and (2S,5S)-Ac-pSer-Ψ[(Z)CH = C]-pipecolyl(Pip)-2-(2-naphthyl)ethylamine 1, that mimic L-pSer-D-Pro, D-pSer-L-Pro, and D-pSer-D-Pro amides respectively, were synthesized by a 13-step route. The newly formed stereogenic centers in the pipecolyl ring were introduced by Luche reduction, followed by stereospecific [2,3]-Still-Wittig rearra...

The NMR solution structures at different levels of refinement of three different 2 S albumin seed proteins, the recombinant pronapin precursor from Brassica napus, the recombinant RicC3 from Ricinus communis and the methionine-rich protein from sunflower ( Helianthus annuus ), are described. The resulting common structure consists of a bundle of five alpha-helices, folded in a right-handed supe...

BACKGROUND (2S)-Pinocembrin is a chiral flavanone with versatile pharmacological and biological activities. Its health-promoting effects have spurred on research effects on the microbial production of (2S)-pinocembrin. However, an often-overlooked salient feature in the analysis of microbial (2S)-pinocembrin is its chirality. RESULTS Here, we presented a full characterization of absolute conf...