The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by pho...

Stimulation of the 2-adrenergic receptor ( 2AR) in human embryonic kidney (HEK) 293 cells causes a transient activation of Extracellular Signal-Regulated Kinase (ERK) 1/2. One of the mechanisms proposed for this activation is a PKA-mediated phosphorylation of the 2AR that switches receptor coupling from Gs to Gi and triggers internalization of the receptor. To examine these phenomena, we charac...

This study shows the signaling pathway by which cilostazol suppresses tumor necrosis factor(TNF)-induced the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) phosphorylation and apoptosis via casein kinase 2 (CK2) phosphorylation in the SK-N-SH cells (neuroblastoma cells). Cilostazol (10 M) fully restored cell proliferation with suppression of DNA fragmentation induced by TNFand...

Using market mechanisms for resource allocation in distributed systems is not a new idea, nor is it one that has caught on in practice or with a large body of computer science research. Yet, projects that use markets for distributed resource allocation recur every few years [1, 2, 3], and a new generation of research is exploring market-based resource allocation mechanisms [4, 5, 6, 7, 8] for d...

Cardiovascular sensitivity to general anesthetics is highly variable among individuals in both human and animal models, but little is known about the genetic determinants of drug response to anesthetics. Recently, we reported that propofol (2,6-diisopropylphenol) causes circulatory instability in Dahl salt-sensitive SS/JRHsdMcwi (SS) rats but not in Brown Norway BN/ NHsdMcwi (BN) rats and that ...

Understanding the circumstances under which talker (and other types of) variability affects language perception represents an important area of research in the field of spoken word recognition. Previous work demonstrates that talker effects are more likely when the processing is relatively slow (McLennan & Luce, 2005). Given that listeners may take longer to process foreign-accented speech than...