PURPOSE Several studies reported the increased risk of second primary pancreatic ductal adenocarcinoma (2nd PDAC) in cancer survivors. However, data on the characteristics of 2nd PDAC are insufficient. METHODS This retrospective cohort study included 1759 patients with PDAC. They were classified as having 2nd PDAC or first primary PDAC (1st PDAC) according to a prior diagnosed cancer of diffe...

The visual system can use a rich variety of contours to segment visual scenes into distinct perceptually coherent regions. However, successfully segmenting an image is a computationally expensive process. Previously we have shown that exogenous attention—the more automatic, stimulus-driven component of spatial attention—helps extract contours by enhancing contrast sensitivity for 2nd-order, tex...

This study examines the relation of language arts instruction to students’ letter-word reading skill growth from the beginning of 1st grade to the end of 2nd grade using cross-classified random effects models. Amounts of teacher-managed, code-focused instruction in 1st and 2nd grade each uniquely predicted students’ letter-word reading skill growth; plus, there were child-by-instruction interac...

aretaeus of cappadokia, lived in an era when cancer was already a disease, well known for its deadly outcome. inside his momentous treatise, composed of 8 books, he had outlined various types of cancer. he had understood cancer’s fatality and proposed some curative treatments. our manuscript composes the fragments related to cancer, in an effort to present aretaeus’ views on the matter.  he had...

Extranodal spread (ENS) in patients with head and neck squamous cell carcinoma (HNSCC) can greatly influence the prognostic outcomes. However, the relative risks of ENS in the primary (1st) and secondary (2nd) metastatic nodes (mets) are not well documented. We retrospectively analyzed the hazard ratios (HRs) of ENS in the 1st and 2nd mets from 516 HNSCC patients who had undergone primary tumor...

OBJECTIVE To determine frequency, demographic and treatment characteristics of patients with an overlapping second autoimmune illness (2nd AI). METHODS We analysed two cohorts containing 897 patients with 'pure' systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome or antiphospholipid syndrome (APS) and 424 patients with one of these diagnoses plus at least one 2nd...

The ninth month of Islamic calendar is known as Ramadan, in which fasting is obligatory for every adult man and woman, except in certain health conditions and during travelling. Since Islamic jurisprudence follows the lunar calendar, which is about 11 days shorter than the Gregorian, Ramadan falls in different seasons throughout the year. The duration of fasting hence may differ by 11 to 18 hou...

Neurons in early visual cortex respond to both luminance- (1st order) and contrast-modulated (2nd order) local features in the visual field. In later extra-striate areas neurons with larger receptive fields integrate information across the visual field. For example, local luminance-defined features can be integrated into contours and shapes. Evidence for the global integration of features defin...

The treatment of Ph-positive acute lymphoblastic leukemia (Ph+ ALL) has entranced tyrosine kinase inhibitors (TKIs) era. Currently both imatinib and dasatinib are registered as the front-line treatment for Ph+ ALL, and the other 2nd-generation TKIs are suggested as an alternative for those who failed the first-line treatment. However, it remains unclear who could benefit from the 2nd-generation...

BACKGROUND/AIMS Endoscopic submucosal dissection (ESD) was originally developed in 1995 using an insulation-tipped diathermic knife (Olympus, Tokyo, Japan) to achieve en-bloc resection of early gastric cancer (EGC). It has been suggested that advances in endoscopic devices and medical equipment, such as the high-frequency generator (1999) and hemostatic forceps (2000), and procedural improvemen...