Signals mediated by fibroblast growth factor (FGF) family members are transduced into target cells by tyrosine kinase transmembrane receptors (FGFRs). The FGFR family includes four distinct receptors, FGFR-1, −2, −3 and -4 which share a common general structure. The extracellular domain contains three immunoglobulin-like domains. The first and the second domains are separated by a stretch of ac...

The front cover picture was designed by C. Zippel, Z. Hassan and S. Bräse. Kinetic resolution of 4-acetyl[2.2] paracyclophane via ruthenium-catalyzed enantioselective hydrogenation has been realized. This method can be performed on a multigram-scale gives access to enantiomerically pure derivatives with planar central chirality (Rp)-4-acetyl-PCP (97% ee, 43%) (Sp,S)-PCP 46%), which are useful i...

their movements, coupling between action and perception is probably essential to ensure high accuracy in maintaining a specific trajectory that is followed by the animal (Heisenberg and Wolf, 1988). Bats are good model systems for studying the interaction between sensory and motor systems because they use echoes from calls generated by their motor systems as sensory information. Bats cannot per...

In this postgenomic era, the ability to identify protein-protein interactions on a genomic scale is very important to assist in the assignment of physiological function. Because of the increasing number of solved structures involving protein complexes, the time is ripe to extend threading to the prediction of quaternary structure. In this spirit, a multimeric threading approach has been develop...

Background Both obesity and sleep disorders are common among women during pregnancy. Although prior research has identified a relationship between disorders, those findings from later in Objective To explore the relationships self-reported duration, insufficient snoring with body mass index (BMI) multiethnic at risk of gestational diabetes mellitus (GDM)in early Methods Cross-sectional study ba...

The question of how to promote the growth and diffusion of information has been extensively addressed by a wide research community. A common assumption underpinning most studies is that the information to be transmitted is useful and of high quality. In this paper, we endorse a complementary perspective. We investigate how the growth and diffusion of high quality information can be managed and ...

We elucidate the effects of incorporating surfactants into electrospun poly (ɛ-caprolactone) (PCL) scaffolds on network homogeneity, cellular adherence and osteogenic differentiation. Lecithin was added with a range of concentrations to PCL solutions, which were electrospun to yield functionalized scaffolds. Addition of lecithin yielded a dose-dependent reduction in scaffold hydrophobicity, whi...

Introduction The periods of lockdown during 2020 led to changes in daily occupations. As participation relies on dynamic interactions between the person, his/her occupations and environment, we wondered whether people from different generations shared same perception occupational disruptions lockdown. Methods We performed an online survey based Canadian Occupational Performance Measure (COPM) a...

The Jinsha River, upstream of the Yangtze flows through southeastern margin plateau, providing an opportunity to study plateau uplift relative Sichuan basin fluvial geomorphology. Eight tributaries River located at transition boundary from were analyzed for feature longitudinal profile and its evolution. spatial distribution slope-break knickpoints in catchment was determined by slope-area anal...