III. SECURITIES MARKET INTERMEDIARIES ............................................. 283 A. Securities Analysts ....................................................................... 283 B. Auditors........................................................................................ 291 C. Proxy Advisory Services .............................................................. 294 D. Sharehold...

The non-receptor tyrosine kinase c-Src is an important mediator in several signaling pathways related to neuroinflammation. Our previous study showed that cortical injection of kainic acid (KA) promoted a transient increase in c-Src activity in reactive astrocytes surrounding the neuronal lesion. As a cell-penetrating peptide based on connexin43 (Cx43), specifically TAT-Cx43266-283, inhibits Sr...

INTRODUCTION 272 CLINICAL ASPECTS OF OBESITY AND CARDIOMETABOLIC DISEASE 273 Background – Do We Need Drugs for Obesity? 273 Current Drugs for Obesity and Their Limitations 274 Other Drugs – Withdrawn or No Longer Recommended for Routine Clinical Use 275 The Need for New Drugs 275 BIOLOGY AND GENETICS OF ENERGY REGULATION AND IMPLICATIONS FOR OBESITY 276 Short-Term (Episodic) Signals 276 Meal On...

Explanation ..................................................................................................... 227 Evaluation for acceptable daily intake ............................................................ 228 1. Biochemical aspects .......................................................................... 228 1.1 Absorption, distribution and excretion .................................

BACKGROUND Asthma is a chronic airway disease that has a significant impact on patients with substantial global socioeconomic burden. Appropriate knowledge by health care practitioners is important in the management of asthma. AIM The aim was to assess the knowledge of asthma among doctors practicing in health care facilities in three South-Eastern states of Nigeria. SUBJECTS AND METHODS Th...

Connexin43 (CX43), a protein that forms gap junction channels and hemichannels in astrocytes, is downregulated in high-grade gliomas. Its relevance for glioma therapy has been thoroughly explored; however, its positive effects on proliferation are counterbalanced by its effects on migration and invasion. Here, we show that a cell-penetrating peptide based on CX43 (TAT-Cx43266-283) inhibited c-S...

Explanation.................................................................................................... 275 Evaluation for acceptable daily intakes ........................................................ 276 Biochemical aspects ................................................................................ 277 Absorption distribution and excretion ........................................

To understand the situation of water contamination with Cryptosporidium spp. and Giardia spp. in the northern region of Portugal, we have established a long-term program aimed at pinpointing the sources of surface water and environmental contamination, working with the water-supply industry. Here, we describe the results obtained with raw water samples collected in rivers of the 5 hydrographica...