Comprehensive and accurate identification of structural variations (SVs) from next generation sequencing data remains a major challenge. We develop FusorSV, which uses a data mining approach to assess performance and merge callsets from an ensemble of SV-calling algorithms. It includes a fusion model built using analysis of 27 deep-coverage human genomes from the 1000 Genomes Project. We identi...

It has been proposed that in humans 4b-hydroxycholesterol is formed mainly by CYP3A-catalyzed metabolism of cholesterol and thus may serve as an endogenous marker for CYP3A activity. The cynomolgus monkey is widely used as one of the nonrodent preclinical safety species in pharmaceutical research. In the current study, the potential application of 4b-hydroxycholesterol as an endogenous biomarke...

We examined whether the glia limitans (GL) influences pial arteriolar relaxation elicited in vivo by the purinergic (P(2)Y(1) receptor) agonist ADP in female rats, and whether that influence is altered in ovariectomized (Ovx) females. A validated model for GL injury was used, topical application of the gliotoxin L-alpha-aminoadipic acid (L-alphaAAA), 24 h before the study. In both intact and Ov...

Immune complexes containing human gamma (g)l or murine g2a antibodies generate secondary erector mechanisms via Fc receptor binding or complement activation, whereas those containing human g4 or murine gl antibodies generally do not. Therefore, isotype selection of therapeutic antibodies may have important clinical consequences. In a rabbit model of recombinant human tumor necrosis factor (rhuT...

Immune complexes containing human gamma (g)l or murine g2a antibodies generate secondary erector mechanisms via Fc receptor binding or complement activation, whereas those containing human g4 or murine gl antibodies generally do not. Therefore, isotype selection of therapeutic antibodies may have important clinical consequences. In a rabbit model of recombinant human tumor necrosis factor (rhuT...

Corresponding author: 13 Robert F. Hess 14 McGill Vision Research (H4.14) 15 Department of Ophthalmology 16 687 Pine Ave West, Montreal 17 Quebec, Canada H3A 1A1 18 Tel: 514 843 1690 19 20 Email: [email protected] 21 22 23 Running head: geniculo-cortical processing in Amblyopia 24 Figures: 6 25 Tables: 2 26 Pages: 23 27 Word counts: 210 (Abstract), 642 (Introduction), 1188 (Discussion) 28 2...

It has been proposed that in humans 4b-hydroxycholesterol is formed mainly by CYP3A-catalyzed metabolism of cholesterol and thus may serve as an endogenous marker for CYP3A activity. The cynomolgus monkey is widely used as one of the nonrodent preclinical safety species in pharmaceutical research. In the current study, the potential application of 4b-hydroxycholesterol as an endogenous biomarke...

background: gastric lavage (gl) is one of the most commonly used decontamination method for cholinergic insecticide ingestion in developing countries despite lack of supporting evidence. this study was designed to evaluate the outcome of patients with cholinergic insecticide poisoning treated with gl in regards to timing and frequency of the procedure. methods: in this prospective observational...