introduction: elective upper and lower gi endoscopy is usually performed in children on an outpatient basis with the child under sedation or general anesthesia (ga). the objective of this study was to describe anesthesia related complications in   children undergoing elective gi endoscopy.   materials and methods: the study design was descriptive on 1388 patients undergoing elective gi endoscop...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, myeloid dendritic cells (mDCs) secrete elevated amounts of IL-23, a potent proinflammatory cytokine, compared to healthy donors. Here, we examined the role of CD46, a complement binding factor, in mDCs by analyzing cytokine and chemokine production in healthy donors and patients with MS. There ...

Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, w...

Vol. 26 No. 1, 2014 139 Received December 7, 2012, Revised February 5, 2013, Accepted for publication March 31, 2013 Corresponding author: Hong Sang, Department of Dermatology, Jinling Hospital, Southern Medical University (Guangzhou) School of Medicine, 305 E Zhongshan Road, Nanjing 210002, Jiangsu Province, China. Tel: 86-25-8086-0092, Fax: 86-25-8481-5775, E-mail: [email protected] This is...

PURPOSE The interleukin-23 receptor (IL-23R) has been shown to be associated with ankylosing spondylitis (AS) in many different populations. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS Three single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, and rs17375018, were genotyped in 291 AS patient...