Background: There is limited research on the effects of physical activity with moderate intensity βklotho (BKL) and fibroblast growth factor-21 (FGF-21) proteins expression in diabetic patients non-alcoholic fatty liver disease (NAFLD). Objectives: This study was aimed to determine eight weeks endurance resistance training BKL FGF-21 women NAFLD. Methods: Forty-five (age: 51 ± 8 years, height: ...

Two papers in the Journal this month report on results from the Christchurch Psychotherapy of Depression Study, a randomised controlled trial of interpersonal psychotherapy and cognitive–behavioural therapy (CBT) involving an out-patient sample. Luty et al (pp. 496–502) found no significant difference in efficacy between the two treatment groups, with overall improvements in depressive symptoma...

Healing of corneal alkali injuries remains a severe clinical challenge. The authors evaluated the effect of a new synthetic inhibitor of matrix metalloproteinases (GM6001 or N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-L-tryptophane methylamide) on preventing ulceration of rabbit corneas after alkali injury. Topical treatment of corneas with severe alkali injuries with 400 microgra...

Three papers in the Journal this month consider issues related to outcomes and treatment in first-episode psychosis. Crossley et al (pp. 434–439) reviewed 15 randomised controlled trials of antipsychotic treatment in first-episode psychosis and found no evidence for differences in discontinuation rates or effect on symptoms between atypical and typical antipsychotics. Clear differences in side-...

Inflammation appears to be the cause of aortic valve (AoV) stenosis and identification of predictive biomarkers is therefore imperative. The aim of the current study was to evaluate the potential role of serum chemerin and fibroblast growth factor-21 (FGF-21) in the pathogenesis of the disease. A total of 102 patients were selected based on certain criteria and divided into an aortic stenosis g...

BACKGROUND Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in no...

BACKGROUND Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES To examine the association of serum IgE levels and the clinical severity of injuries. METHODS This case-control stud...