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congenital hepatic fibrosis (chf) is a rare disease that affects both the liver and kidneys. congenital hepatic fibrosis (chf) is an autosomal recessive inherited malformation defined pathologically by a variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. affected individuals also have impaired renal function, usually caused, in children and teenagers, by an...
— Recently there are so many media contents created and used by variety routes. Therefore, it is essential to make a new platform which is used for distributing media contents include IPTV. With open IPTV service, developing the new platform became even more important. Because open IPTV makes it possible for consumers to choose contents regardless of contents of the providers. The new platform ...
یکی از نکات بسیار مهم و حیاتیدر مطالعه و طراحی سازه های دریایی،انجام مطالعات هیدرودینامیکی (شامل مطالعات باد، موج و جریان) می باشد. این مطالعات برای تعیین پارامترهای پیش نیاز طراحی سازه ها و همچنین محاسبه بارگذاریآن هاضروری می باشند. بنابراین نیاز است تا با برپایی مدل های دقیق نرم افزاری، پارامترهای هیدرودینامیکی نظیر پریود و ارتفاع امواج و همچنین ترازهای جزر و مدی تعیین گردند. در این راستا، یک...
The IL21R gene is comprised of 9 exons (+2 alternative first exons), spanning 48.4kb on chromosome 16p11 (Parrish-Novak, 2000). The human IL21R promoter region, contained within nucleotides -789 to +195 (relative to the start of exon 1a) induces the high levels of transcription in reporter assays (Ueda, 2002). A critical SP1 binding site is contained in the region from -80 to -20 and is essenti...
BACKGROUND Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4(+) cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis. OBJECTIVE This study was performed to investigate the impact of genetic p...
Chronic viral infection is often associated with the dysfunction of virus-specific T cells. Our studies using Il21r-deficient (Il21r-/-) mice now suggest that interleukin-21 (IL-21) is critical for the long-term maintenance and functionality of CD8+ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice. Cell-autonomous IL-21 receptor (IL-21R)-dependent signalin...
The aim of this study is to determine the effects of aerobic training on serum FGF21 levels and glucose in women with type II diabetes mellitus. Women with type II diabetes mellitus were divided into two groups including control (n=14) and aerobic training (n=14) the mean levels of serum FGF21, glucose were measured in all participants after 8 weeks exercise. The mean of FGF21 levels after exer...
Purpose of developing the guidelines: The first guidelines for diagnosis and treatment of 21-hydroxylase deficiency (21-OHD) were published as a diagnostic handbook in Japan in 1989, with a focus on patients with severe disease. The "Guidelines for Treatment of Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency) Found in Neonatal Mass Screening (1999 revision)" published in 1999 were rev...
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