IL-20, an IL-10 family member, is involved in various inflammatory diseases, such as psoriasis, rheumatoid arthritis, and atherosclerosis. We investigated whether hypoxia in vitro and an in vivo model of ischemic stroke would up-regulate IL-20 expression. In vitro, IL-20 expression increased in hypoxic HaCaT, HEK293 cells, chondrocytes, monocytes, and glioblastoma cells. Inhibition of hypoxia-i...

Background Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) for the pathologic in CRS. Elevation interleukin (IL)-19 or MMP-9 levels patients with CRS had been proven previous studies. Here, we aimed to investigate role IL-19 mediating expression Methods Nasal samples were collected fr...

The soluble extracellular domains of human interleukin-20 (IL-20) receptors I and II (sIL-20R1 and sIL20R2), along with their ligands IL-19 and IL-20, were expressed in Drosophila S2 cells and purified to homogeneity. Formation of the receptor/receptor and ligand/receptor complexes was studied by size exclusion chromatography. Both ligands and soluble receptors were found to be monomeric in sol...

Lichens are considered by researchers as bioindicators of environmental pollution artificial radionuclides, including 137Cs. One these bioindicator species is epiphytic lichen Hypogymnia physodes (L.) Nyl, the use which for radioecological monitoring can be modified several factors: tree species, placement on (branches – trunk), height sampling, etc. The purpose this study was to investigate sp...

Interleukin-26 (IL-26) is one of the cytokines secreted by Th17 cells whose role in human tumors remains unknown. Here, we investigated the expression and potential role of IL-26 in human gastric cancer (GC). The expression of IL-26 and related molecules such as IL-20R1, STAT1 and STAT3 was examined by real-time PCR and immunohistochemisty. The effects of IL-26 on cell proliferation and cisplat...