programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...

ba ckground: obesity is a consequence of the excessive accumulation of fat in adipose tissue which can result in significant morbidity and mortality. obesity is a major health problem in iran.  objective: the aim of this study was to investigate the  effects of  epa consumption on bmi  and  fasting blood sugar by fabp2 genotypes and pparα (leu162val, and g/c intron polymorphism) genotypes.   m ...

objective(s): adeno-associated virus type 2 (aav2) vectors are widely used for both experimental and clinical gene therapy. a recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. in this study, a fast and simple method is presented to generate aav2 vector helper plasmids encodin...

abstract      background and objective: diabetes mellitus is the most common risk factor for coronary artery disease (cad). cholesteryl ester transfer protein (cetp) taqib polymorphism is associated with changes in lipid profile and may be a risk factor for cad in patients with diabetes. this study aimed to evaluate the association of cetp taqib polymorphism with cad in patients with type 2 dia...

background: retinol?binding protein 4 (rbp4) is known to regulate lipid and glucose metabolism and insulin resistance. the influences of rbp4 on metabolic syndrome (ms) are still unclear. the purpose of this study is to evaluate the association between serum levels of rbp4 and ms components in first?degree relations of type 2 diabetic patients. materials and methods: this cross?sectional study ...

abstract       background and objectives: diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. it is thought that the use of medicinal plants, particularly portulaca oleracea. l and regular exercise are effective. the aim of this study was to evaluate the effects of portulaca oleracea. l consumpt...

objective: the incidence of breast cancer is approximately one million which makes this cancer one of the most common among women worldwide. breast cancer comprises 7% of the total death rate caused by cancers. several strategies that use tumor-associated antigen (taa) vaccination and early detection of breast cancer are clinically being developed. breast cancer is caused by increased over expr...