Centrosomes are major microtubule organising centres comprising a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, and we previously showed that two key PCM components, Centrosomin (Cnn) and Spd-2, cooperate to form a scaffold structure around the centrioles that recruits the mitotic PCM in Drosophila; the SPD-5 and SPD-2 prote...

BACKGROUND centrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has recently been shown that the two centrosomes in certain stem cells are often asymmetric in size. There is compelling evidence that centrioles influe...

Background: Acetaminophen (Paracetamol; PCM), commonly utilized as analgesic and antipyretic drug in many painful and febrile disorders, has been found to induce liver and renal disorders in both animals and humans. Its administration in a high dose causes hepatic and renal toxicities and results in hepato-renal cell deaths by activating multiple stress pathways. Objective: This study aimed to ...

Background and study aims The pocket-creation method (PCM) is a novel strategy for endoscopic submucosal dissection (ESD). The aim of this study is to determine the efficacy of the PCM for colorectal laterally spreading tumors, non-granular type (LST-NG). Patients and methods The records of 126 consecutive patients with colorectal LST-NG who underwent ESD between April 2012 and July 2015 were r...

We describe a new architecture for passive robots and haptic displays, which we call a programmable constraint machine (PCM). An n-dof PCM can, under computer control, exhibit constraints (smooth, impenetrable virtual surfaces of dimensionality < n), or it can allow free n-dof motion. At the heart of the PCM is a nonholonomic element, which is used as a continuously variable transmission (CVT)....

We describe a new architecture for passive robots and haptic displays, which we call a programmable constraint machine (PCM). An n-dof PCM can, under computer control, exhibit constraints (smooth, impenetrable virtual surfaces of dimensionality < n), or it can allow free n-dof motion. At the heart of the PCM is a nonholonomic element, which is used as a continuously variable transmission (CVT)....

A new simple and sensitive ratio-spectra first derivative spectrophotometric method was developed for the simultaneous determination of tapentadol hydrochloride (TPH) and paracetamol (PCM) in binary mixtures. The method depends on the use of the first derivative of the ratio-spectra obtained by dividing the absorption spectrum of binary mixture by a standard spectrum of one of the compounds. TP...

This paper presents experimental results that can be applied to select a possible phase change material (PCM), such as a latent heat material (LHM), to control the hydration heat in mass concrete structures. Five experimental tests (microconduction, simplified adiabatic temperature rise, heat, and compressive strength tests) were conducted to select the most desirable LHM out of seven types of ...

Phase change memory (PCM) is a promising alternative to DRAM, though its high latency and energy costs prohibit its adoption as a drop-in DRAM replacement. Hybrid memory systems comprising DRAM and PCM attempt to achieve the low access latencies of DRAM at the large capacities of PCM. However, known solutions neglect to assess the utility of data placed in DRAM, and hence fail to achieve high p...

Six approaches for downscaling climate model outputs for use in hydrologic simulation were evaluated, with particular emphasis on each method’s ability to produce precipitation and other variables used to drive a macroscale hydrology model applied at much higher spatial resolution than the climate model. Comparisons were made on the basis of a twenty-year retrospective (1975– 1995) climate simu...