Pathological cardiac hypertrophy is associated with an increased risk of heart failure and cardiovascular mortality. Calcium (Ca(2+)) -regulated gene expression is essential for the induction of hypertrophy, but it is not known how myocytes distinguish between the Ca(2+) signals that regulate contraction and those that lead to cardiac hypertrophy. We used in vitro neonatal rat ventricular myocy...

Abstract Raf kinases signal via extracellular signal-regulated 1/2 (ERK1/2) to drive cell division. Since activating mutations in BRAF (B-Raf proto-oncogene, serine/threonine kinase) are highly oncogenic, inhibitors including dabrafenib have been developed for cancer. Inhibitors of ERK1/2 signalling used cancer cardiotoxic some patients, raising the question whether is cardiotoxic. In heart, pr...

Thyroid hormone (TH) is critical for cardiac development and heart function. In heart disease, TH metabolism is abnormal, and many biochemical and functional alterations mirror hypothyroidism. Although TH therapy has been advocated for treating heart disease, a clear benefit of TH has yet to be established, possibly because of peripheral actions of TH. To assess the potential efficacy of TH in ...

This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. The expression of SCAD was lowest in the foetal and neonatal heart, which had time-dependent increase during normal heart development. In con...

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids can lower decrease thickening. To determine the effect of bay (Syzygiumpolyanthum) on ventricle thickening rat (Rattus norvegicus wistar strain) in hypertensive model. T...

In chronic kidney disease, activation of the epidermal growth factor receptor (EGFR) leads to cardiac hypertrophy, which affects morbidity and mortality. In patients with renal insufficiency and heart failure, the expression of midkine, a heparin-binding growth factor, is increased. Therefore, we investigated the association between midkine and EGFR in the induction of cardiac hypertrophy and d...

Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 r...

The present study was designed to evaluate the cardioprotective effect of fenofibrate against isoproterenol (ISO) induced heart failure (HF) in rats by studying cardiac injury markers, left ventricular hypertrophy and electrocardiographic changes. Rat model of HF was induced by ISO administration (85 mg/kg, s.c.) at an interval of 24h on 0 and 1st day. Fifteen days post ISO injection, rats show...

objective(s):to examine the expressions of cd11a, cd11b, and cd11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. this study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. materials and methods: a myocardial hypertrophy model was established by subcutaneously injecting i...

Caspase-activated DNase (CAD) is a double-strand-specific endonuclease that is responsible for the cleavage of nucleosomal spacer regions and subsequent chromatin condensation during apoptosis. Given that several endonucleases (eg, DNase I, DNase II, and Endog) have been shown to regulate pathological cardiac hypertrophy, we questioned whether CAD, which is critical for the induction of DNA fra...