Betafectin PGG-Glucan, a novel beta-(1,6) branched beta-(1,3) glucan purified from the cell walls of Saccharomyces cerevisiae, has been shown to synergize with myeloid growth factors in vitro and to enhance hematopoietic recovery in myelosuppressed mice and primates. Here we report that PGG-Glucan is also capable of mobilizing peripheral blood progenitor cells (PBPC). PGG-Glucan (0.5 mg/kg to 1...

Purpose: In vitro -glucan can enhance tumor cytotoxicity through iC3b receptors on leukocytes. We tested if (133),(134)-D-glucan ( -glucan) can synergize with antiGD2 monoclonal antibody (MoAb) 3F8 (mouse IgG3) in therapy of human neuroblastoma xenografts. Experimental Design: Athymic nude mice with established neuroblastoma xenografts were treated with daily i.p. or p.o. -glucan, in the presen...

considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (ua), a soluble salt of depleted uranium (du). we examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (bht), to prevent ua-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. beta-glucan (150 nm) and bht (20 nm) attenuated ua-indu...

it is well known that several plant extracts have a lactogenic effect. this response may be inducedthrough the stimulation of prolactin release from lactotrope cells. a partial purification of the activecompound indicated that it is rich in pectin and β-glucan. these materials stimulate secretion of prolactinfrom hypophyseal fragments. in the present study, the effect of β-glucan on the secreti...

Soluble fibre b-glucan is one of the key dietary materials in the healthy food products known for reducing serum cholesterol levels. The micro-structural heterogeneity and micro-rheology of high-viscosity oat b-glucan solutions were investigated by monitoring the thermally driven displacements of well-dispersed microspheres via video fluorescence microscopy. By comparing the distribution of the...

CONTEXT The recent events increasing the threat of bioterrorism have prompted a widespread search for defenses against this peril. OBJECTIVE To evaluate the anthrax-protective effect of beta1,3-glucan immune modulators (PGG-glucan and WGP beta glucan) in an experimental animal model. DESIGN Beta1,3-glucan immune modulators were administered by subcutaneous injection to Balb/c mice 2 days pr...

Several regulatory bodies have approved a health claim on the cholesterol-lowering effects of oat β-glucan at levels of 3·0 g/d. The present study aimed to test whether 1·5 g/d β-glucan provided as ready-to-eat oat flakes was as effective in lowering cholesterol as 3·0 g/d from oats porridge. A 6-week randomised controlled trial was conducted in eighty-seven mildly hypercholesterolaemic ( ≥ 5 m...

Several regulatory bodies have approved a health claim on the cholesterol-lowering effects of oat b-glucan at levels of 3·0 g/d. The present study aimed to test whether 1·5 g/d b-glucan provided as ready-to-eat oat flakes was as effective in lowering cholesterol as 3·0 g/d from oats porridge. A 6-week randomised controlled trial was conducted in eighty-seven mildly hypercholesterolaemic ($5 mmo...

Studies show that Oryza sativa L. contains a structure named β-glucan with anti cancer properties. In the present study, a tissue culture for rice was carried out and β-glucan content was measured under various sugar and vitamin levels in basic MS medium. Seeds of Hashemi cultivar were cultured on MS medium. Two plant hormones, namely, 2,4-D (0, 1, 1.5, 2 and 3 mg/l) and kinetin (0,0.5, 1, and ...

BACKGROUND Simultaneous saccharification and fermentation (SSF) is a promising process for bioconversion of lignocellulosic biomass. High glucan loading for hydrolysis and fermentation is an efficient approach to reduce the capital costs for bio-based products production. The SSF of steam-exploded corn stover (SECS) for ethanol production at high glucan loading and high temperature was investig...