The contribution of human atrial fibroblasts to cardiac physiology and pathophysiology is poorly understood. Fibroblasts may contribute to arrhythmogenesis through fibrosis, or by directly altering electrical activity in cardiomyocytes. The objective of our study was to uncover phenotypic differences between cells from patients in sinus rhythm (SR) and chronic atrial fibrillation (AF), with spe...

During the period of life that precedes weaning, the facial nucleus of the newborn rat is rich in 3H-vasopressin binding sites, and exogenous arginine vasopressin (AVP) can excite facial motoneurons by interacting with V1 (vasopressor-type) receptors. We have investigated the mode of action of this peptide by carrying out single-electrode voltage-clamp recordings in coronal brainstem slices fro...

Information on genetic variation within and between populations is critical for understanding the evolutionary history of mosquito populations and disease epidemiology. Previous studies with Drosophila suggest that genetic variation of selectively neutral loci in a large fraction of genome may be constrained by fixation of advantageous mutations associated with hitchhiking effect. This study ex...

The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry effort led to the discovery of an improved mTOR inhibitor 3 (Torin2), which possesses an EC(50) of 0.25 nM for inhibiting cellular mTOR activity. Compound 3 exhibited 800-fold sel...

we give the concept of ‘braiding’ for 2-groupoids, and we show that this structure is equivalent tobraided regular, crossed modules.

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In this paper, we introduce the concepts of $2$-isometry, collinearity, $2$%-Lipschitz mapping in $2$-fuzzy $2$-normed linear spaces. Also, we give anew generalization of the Mazur-Ulam theorem when $X$ is a $2$-fuzzy $2$%-normed linear space or $Im (X)$ is a fuzzy $2$-normed linear space, thatis, the Mazur-Ulam theorem holds, when the $2$-isometry mapped to a $2$%-fuzzy $2$-normed linear space...