Cytogenetic abnormalities including the gain and loss of chromosomes play an important role in oncogenesis. Aberrations involving chromosome 1 are one of the most common anomalies reported among human neoplasms and have been observed in both solid tumors and hematological malignancies. This review highlights the prognostic import of cytogenetic abnormalities involving 1q in childhood cancers an...

OBJECTIVE The aim of this study is to investigate the effect of first chromosome long arm duplication (dup(1q)) in cases with endometrial carcinoma detected with array based comperative genomic hybridization (aCGH) on survival from the cancer. MATERIALS AND METHODS A total of 53 patients with the diagnosis of endometrial carcinom due to endometrial biopsy and who have been operated for this r...

Triplication of the long arm of chromosome 1 (trp(1q)) is a very rare karyotypic abnormality in hematologic diseases. We report a case of acute myelogenous leukemia whose karyotype carried trp(1q) that was proved to be addition to preceding trisomy 8. A 62 year-old woman who visited our department because of general fatigue presented pancytopenia. Bone marrow examination revealed hypocellularit...

Total or partial duplication of chromosome 1q and whole arm translocation can result from unbalanced translocation of chromosomes, isochromosomes or jumping translocations. These structural rearrangements are reported as secondary aberrations associated with tumor progression, and advanced disease. Partial duplication of 1q resulting from der(18)t(1;18)(q12;p11) has been reported in Fanconi ane...

We investigate magnetic domain walls in a single fcc Mn layer on Re(0001) employing spin-polarized STM, atom manipulation, and spin dynamics simulations. The low symmetry of the row-wise antiferromagnetic (1Q) state leads to new type wall which connects rotational 1Q domains by transient 2Q with characteristic 90$^\circ$ angles between neighboring moments. properties depend their orientation wi...

Recently, we reported that 1q/19p co-polysomy predicted poor prognosis in oligodendroglial tumors. In this study, we aimed to retrospectively analyze the prognostic significance of 1q/19p polysomy in two large cohorts of astrocytic gliomas classified by the 2007 and 2016 WHO classification of tumors of the central nervous system. 1q/19p polysomy was detected using the FISH method, and factors t...

Multiple myeloma is incurable by standard approaches because of inevitable relapse and development of treatment resistance in all patients. In our prior work, we identified a panel of macropinocytosing human monoclonal antibodies against CD46, a negative regulator of the innate immune system, and constructed antibody-drug conjugates (ADCs). In this report, we show that an anti-CD46 ADC (CD46-AD...

We consider d-dimensional simplicial complexes which can be PL embedded in the 2ddimensional euclidean space. In short, we show that in any such complex, for any three vertices, the intersection of the link-complexes of the vertices is linklessly embeddable in p2d ́ 1q-dimensional euclidean space. From this observation, we derive a new upper bound on the total number of d-simplices in an embedda...

Human chromosome 1 has been claimed to be a conserved ancestral chromosome of eutherian mammals. However, two small regions from distal 1q (with orthology to mouse chromosome 11) appear to have a different history. These two regions are proposed to have been added to the ancestor of human chromosome 1 as a single block that was subsequently disrupted by a paracentric inversion. The translocatio...