PURPOSE Down syndrome (DS), or trisomia 21, is one of the most common autosomal mutations, with mental impairment as the constant symptom. Proton magnetic resonance spectroscopy (1HMRS) allows evaluation of this metabolism in DS children. The study objective was the morphological evaluation of the brain in magnetic resonance imaging (MRI) and assessment of the metabolic profile obtained by HMRS...

Background Yaq-001 is a non-absorbable, synthetic carbon with high adsorptive capacity for bacterial products including lipopolysaccharide (LPS) and pro-inflammatory cytokines. Studies in cirrhotic rats showed reduced endotoxemia, improvements end-organ dysfunction sensitisation to LPS. The aims of this study were evaluate the safety tolerability decompensated (DC) patients characteris...

P magnetic resonance spectroscopy (1H-MRS) provides a noninvasive tool for assessing brain metabolites in vivo. The precentral gyrus (PG), which functions as the primary motor cortex,1 is considered relevant to some diseases such as amyotrophic lateral sclerosis (ALS), whilst, the hippocampus is a brain center that is sensitive to the effects of stress exposure, and has been demonstrated to be ...

Background and Objectives: The search for accurate biomarkers in Alzheimer Disease (AD), on of the most devastating neurodegenerative diseases, remains essential to enable an early prognosis and diagnosis of the disease and to provide more efficient therapeutic strategies. A wide variety of potential biomarkers are has been identified by neuroimaging techniques and by the analysis of fluid samp...