نتایج جستجو برای: 1f5
تعداد نتایج: 73 فیلتر نتایج به سال:
The interleukin (IL)-1 family members IL-1alpha, -1beta, and -18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Recently, several new IL-1 family members have been identified. To determine the role of one of these family members in the skin, transgenic mice expressing IL1F6 in ...
Rituximab is an anti-CD20 chimeric mAb effective for the treatment of B-NHL. It can lyse lymphoma cells in vitro through both C- and Ab-dependent cellular cytotoxicity. The mechanism of action of rituximab in vivo is however still unclear. We have set up a new in vivo model in nonimmunodeficient mice by stable transduction of the human CD20 cDNA in the murine lymphoma line EL4. Animals injected...
High androgen receptor (AR) level in primary tumour predicts increased prostate cancer-specific mortality. However, the mechanisms that regulate AR function in prostate cancer are poorly known. We report here a new paradigm for the forkhead protein FoxA1 action in androgen signalling. Besides pioneering the AR pathway, FoxA1 depletion elicited extensive redistribution of AR-binding sites (ARBs)...
Monoclonal antibodies are being used as therapeutics for a number of cancers, such as leukemia, breast and colon cancers, and a lot of monoclonal antibodies specific for tumor-related antigens have been on clinical trials. Antibody-dependent cellular cytotoxicity (ADCC) is one of the major mechanisms by which antibodies exert anti-tumor effects. ADCC occurs through interaction between the Fc do...
Transition charge density (TCD) for 0 → 2+1 excitation have been calculated for Ge nuclei within microscopic variational framework employing 2p3/2, 1f5/2, 2p1/2 and 1g9/2 valence space. The calculated TCDs for different monopole variants of Kuo interaction are compared with available experimental results. Other systematics like reduced transition probabilities B(E2) and static quadrupole moment...
In neutron star mergers, excess nuclei and the r-process are important factors governing production of heavier nuclear systems. A single-particle model evaluation silicon suggests that heaviest Z = 14 nucleus will have mass 54 with filling 1f5/2 shell. 43 – isotopes limited experimental half-life data, but predicts beta decay half-lives in range 0.442 8.06 ms. Based on previous calculations for...
We computed ground-state energies of calcium isotopes from Ca to Ca by means of the Auxiliary Field Diffusion Monte Carlo (AFDMC) method. Calculations were performed by replacing the Ca core with a mean-field self consistent potential computed using Skyrme interaction. The energy of the external neutrons is calculated by projecting the ground-state from a wave function built with the single par...
Four patients with refractory malignant B cell lymphomas were treated with continuous intravenous (IV) infusions of murine monoclonal antibody (MoAb) 1 F5 (anti-CD2O) over five to ten days. Dose-dependent levels of free serum 1 F5 were detected in all patients. Two patients had circulating tumor cells and in both cases 90% of malignant cells were eliminated from the blood stream within four hou...
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