In this paper we describe the design and implementation of a 190-MHz pipelined 4-Kbyte instruction and data cache. The caches are designed in 1.0-μm CMOS and measure 0.78 x 0.47 cm2. This paper describes the microarchitecture, cache timing, circuit implementation, and layout of both the instruction and the data cache. The key features of these caches are pipelined execution and the use of dynam...

On a winding open road, a driver consistently looks to the inside of each bend before turning the steering wheel. When researchers disrupt this coordination by instructing drivers not to move their eyes, drivers’ performance is impaired and their completion time during racing increases. The present authors examined whether changing internal states in a way that also restricts eye movements redu...

BACKGROUND While information about 4 million neonatal deaths worldwide is limited, even less information is available for stillbirths (babies born dead in the last 12 weeks of pregnancy) and there are no published, systematic global estimates. We sought to identify available data and use these to estimate the rates and numbers of stillbirths for 190 countries for the year 2000, and provide unce...

OBJECTIVE To investigate how microRNA-190 (miR-190) regulates FOXP2 genes in gastric cancer (GC) cell line SGC7901. METHODS We identified that miR-190 could target FOXP2 genes by using dual luciferase enzyme assay. Precursor fragment transfection of miR-190 was performed with GC cell line SGC7901 and human gastric mucosal cell line GES-1. miR-190 expression was detected by reverse transcripti...

Acute pulmonary oedema has been described in individuals participating in Abstract three aquatic activities: (i) scuba diving; (ii) breath-hold diving; and (iii) endurance swimming. In this review, 60 published cases have been compiled for comparison. Variables considered included: age; past medical history; activity; water depth, type (salt or fresh) and temperature; clinical presentation; inv...

Effects of some selective serotonergic (5-HT) antagonists on methamphetamine-induced anorexia were investigated in male mice. The least possible dose of methamphetamine alone that caused significant anorectic activity was 11 micromolkg(-1), i.p. (2 mgkg(-1)). Various doses of some selective serotonergic receptor antagonists were administered half an hour before the above mentioned dose of metha...