[figure: see text] A catalyst formed in situ from Mo[N(t-Bu)(Ar)]3 1 (Ar = 3,5-dimethylphenyl) and CH2Cl2 in toluene effects cross metathesis reactions of functionalized alkynes that are beyond reach of more traditional promotors. An application to the synthesis of prostaglandin E2 (PGE2) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates.

INTRODUCTION Diagnosis of prostate cancer (PCa) is based on prostate biopsy that is performed when prostate specific antigen (PSA) is persistently altered over time and/or abnormal digital rectal examination is found. Serum PSA levels increase in both PCa and benign prostatic hyperplasia, leading to an increased number of unnecessary biopsies. There is an urgent need to unravel PCa-specific mol...

With-no-lysine kinase 3 (WNK3) is a member of a subfamily of serine/threonine kinases that modulate the activity of the electroneutral cation-coupled chloride cotransporters. WNK3 activates NKCC1/2 and NCC and inhibits the KCCs. Four splice variants are generated from the WNK3 gene. Our previous studies focused on the WNK3-18a variant. However, it has been suggested that other variants could ha...

W 2017 r. członkowie stowarzyszenia „Galea” w okolicy Przezmarka, pow. sztumski, odkryli szereg zabytków archeologicznych. Wśród nich wyróżnia się zachowana fragmentarycznie zapinka wykonana ze stopu miedzi (Ryc. 1). Reprezentuje ona rzadki skali europejskiej typ Almgren 18b typologii T. Völlinga (przyp. 6) datowany na przełom er 9-11). Z tego powodu, zapinki te ziemiach polskich stanowią najwc...

Foetal testosterone and the child systemizing quotient Bonnie Auyeung, Simon Baron-Cohen, Emma Chapman, Rebecca Knickmeyer, Kevin Taylor and Gerald Hackett Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18B Trumpington Road, Cambridge CB2 2AH, UK, Department of Psychiatry, University of North Carolina at Chapel Hill, CB# 7160, Chapel Hill, North Caroli...

Abstract JWST is here. The early release observation (ERO) program provides us with the first look at scientific data and spectral capabilities. One of targets from ERO HAT-P-18b, an inflated Saturn-mass planet equilibrium temperature ∼850 K. We present NIRISS/SOSS transmission spectrum HAT-P-18b 0.6 to 2.8 μ m reveal in infrared beyond 1.6 for time. From spectrum, we see clear water escaping h...

We report the characterization of a transiting hot Jupiter WASP-18b at optical wavelengths measured by exoplanet survey satellite (TESS). analyze publicly available data collected TESS in sector 2. Here, we model systematic noise using Gaussian processes (GPs) and fit it to Markov Chain Monte Carlo (MCMC) method.