نتایج جستجو برای: 185

تعداد نتایج: 10650  

2013
Andrew S. Sage Scott C. Vannest Kuo-Hsien Fan Matthew J. Will Susan Z. Lever John R. Lever Dennis K. Miller

Sigma receptor antagonists diminish the effects of cocaine in behavioral assays, including conditioned place preference. Previous locomotor activity experiments in mice determined that the sigma receptor ligand YZ-185 (N-phenylpropyl-N'-(3-methoxyphenethyl)piperazine) enhanced cocaine-induced hyperactivity at a lower (0.1  μ mol/kg) dose and dose-dependently attenuated cocaine-induced hyperacti...

2015
Lidao Bao Xudong Fu Mingwen Si Yi Wang Ruilian Ma Xianhua Ren Haijun Lv

Diabetes is the most common and complex metabolic disorder, and one of the most important health threats now. MicroRNAs (miRNAs) are a group of small non-coding RNAs that have been suggested to play a vital role in a variety of physiological processes, including glucose homeostasis. In this study, we investigated the role of miR-185 in diabetes. MiR-185 was significantly downregulated in diabet...

1991

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Journal: :The Journal of clinical investigation 1981
M A Simmonds G Sobczak S P Hauptman

We have recently characterized two lymphocyte-associated membrane proteins which have been termed 225,000-dalton and 185,000-dalton macromolecular insoluble cold globulin (225-MICG and 185-MICG, respectively) to distinguish their major physicochemical properties. These proteins differ antigenically, structurally, and in their cellular distribution. T cells can be distinguished by the synthesis ...

Journal: :Journal of lipid research 2014
Muhua Yang Weidong Liu Christina Pellicane Christine Sahyoun Biny K Joseph Christina Gallo-Ebert Melissa Donigan Devanshi Pandya Caroline Giordano Adam Bata Joseph T Nickels

Dysregulation of cholesterol homeostasis is associated with various metabolic diseases, including atherosclerosis and type 2 diabetes. The sterol response element binding protein (SREBP)-2 transcription factor induces the expression of genes involved in de novo cholesterol biosynthesis and low density lipoprotein (LDL) uptake, thus it plays a crucial role in maintaining cholesterol homeostasis....

2018
Li Zhou Shunai Liu Ming Han Yanhua Ma Shenghu Feng Jing Zhao Hongping Lu Xiaoxue Yuan Jun Cheng

Recent studies have shown the effect of microRNAs on HSC activation and transformation, which is essential for the pathogenesis of liver fibrosis. In our study, we explored the role of miR-185 in liver fibrosis. Plasma miR-185 was detected in hepatitis B virus-related liver fibrosis patients (S2/3, n = 10) by Illumina HiSeq sequencing, and healthy volunteers were selected (n = 8) as the control...

Journal: :Journal of immunology 2009
Nolwenn M Dheilly Sham V Nair L Courtney Smith David A Raftos

185/333 genes and transcripts from the purple sea urchin, Strongylocentrotus purpuratus, predict high levels of amino acid diversity within the encoded proteins. Based on their expression patterns, 185/333 proteins appear to be involved in immune responses. In the present study, one- and two-dimensional Western blots show that 185/333 proteins exhibit high levels of molecular diversity within a...

2016
Miao Yu Wei Liang Yu Xie Qi Long Xiang Cheng Yu-Hua Liao Jing Yuan

B cells contribute to the development of dilated cardiomyopathy (DCM) by inducing myocyte injuries and myocardial fibrosis. Our recent research indicated that microRNA (miR) -185 participated in human B-cell activation. Thus, this study was aimed to explore the relationship between miR-185 and DCM progression. Forty-one healthy volunteers and fifty newly diagnosed DCM patients were enrolled. Th...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2016
Duo Zhang Heedoo Lee Yong Cao Charles S Dela Cruz Yang Jin

Lung epithelial cell death is a prominent feature involved in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Hyperoxia-induced ALI is an established animal model mimicking human ARDS. Small noncoding RNAs such as microRNAs (miRNAs) have potent physiological and pathological functions involving multiple disease processes. Emerging interests focus on th...

Journal: :Brain, Behavior and Evolution 1977

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