introduction: hearing loss is the most common sensory neural defect in humans, affecting 1 in 1000 neonates, with over half of these cases predicted to be hereditary in nature. most hereditary hearing loss is inherited in a recessive fashion, accounting for approximately 80 % of non-syndromic hearing loss (nshl). mutations in gjb2 gene are major cause of inherited deafness in the european and a...

while hearing loss has been considered to be a very heterogeneous disorder, mutations in gap junction beta 2 (gjb2) gene encoding connexin 26 (cx26) protein are the major cause of autosomal recessive and sporadic non-syndromic deafness in many populations. in this study, we have investigated the prevalence of the gjb2 gene mutations using nested pcr pre screening strategy and direct sequencing ...

Hearing loss (HL) is an extremely common neurosensory deficit with a heterogeneous etiology including environmental and genetic causes. The incidence of profound sensorineural HL in the United States is 186 per 100,000 births (Morton and Nance 2006). In developed nations, more than 60% of individuals affected with HL have a genetic etiology that can be classified by the mode of inheritance and ...