نتایج جستجو برای: 153sm177lu edtmp

تعداد نتایج: 131  

Akbar Anvari Ali Bahrami-Samani, Amir Reza Jalilian Hassan Yousefnia Mahmoud Reza Aghamiri Mohammad Ghannadi-Maragheh Simindokht Shirvani-Arani

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

Journal: :Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2003
Rong Fu Wang Chun Li Zhang Shou Li Zhu Mei Zhu

OBJECTIVE To assess the therapeutic efficacy and toxicity of samarium-153-ethylenediaminetetramethylene phosphonic acid ((153)Sm-EDTMP) and pamidronate disodium in patients with painful metastatic bone cancer. SUBJECTS AND METHODS Eighteen patients with histopathologically confirmed malignancy and multifocal bone metastases were randomized into two equal groups of 9 patients each. Group A was...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Peter M Anderson Gregory A Wiseman Linda Erlandson Vilmarie Rodriguez Barbara Trotz Stephen A Dubansky Karen Albritton

Osteoblastic metastases and osteosarcoma can avidly concentrate bone-seeking radiopharmaceuticals. We sought to increase effectiveness of high-dose (153)Samarium ethylenediaminetetramethylenephosphonate (153Sm-EDTMP, Quadramet) on osteosarcomas using a radiosensitizer, gemcitabine. Fourteen patients with osteoblastic lesions were treated with 30 mCi/kg 153Sm-EDTMP. Gemcitabine was administered ...

Journal: :iranian journal of radiation research 0
f. johari daha radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran s. shafiei radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran sh. sheibani radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran y.h. tavakoli radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran m. mazidi radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran m.h. mirfalah radioisotope department, nuclear science research school, nuclear science and technology research institute, atomic energy organization of iran, tehran, iran

background: owing to its favourable decay characteristics 177lu [t1/2= 6.71 d, eβ(max)= 497 kev] is an attractive radionuclide for various therapeutic applications. ethylene diamine tatramethylene phosphonate (edtmp) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. materials and methods: enriched 176lu2o3 was dissolved in 0.1 n...

Journal: :Revista do Hospital das Clinicas 2004
Marcelo Tatit Sapienza Carla Rachel Ono Maria Inês Cury Guimarães Tomoco Watanabe Paulo Aguirre Costa Carlos Alberto Buchpiguel

PURPOSE The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months af...

2015
Simindokht Shirvani Arani* Somaye Ghasemi Ali Bahrami Samani Mojtaba Shamsaei Zafarghandi

INTRODUCTION Particle-emitting, bone-seeking radiopharmaceuticals have attracted the attention of the nuclear medicine community over the last three decades for the treatment of the pain of osteoblastic metastases. The objectives of this research were to produce quality-controlled (159)Gd-EDTMP in order to provide a new therapeutic radiopharmaceutical for use in clinical applications. METHODS...

F. Johari Daha, M. Mazidi, M.H. Babaei, M.H. Mirfalah, S. Shafiei, Sh. Sheibani, Y.H. Tavakoli,

Background: Owing to its favourable decay characteristics 177Lu [T1/2= 6.71 d, Eβ(max)= 497 keV] is an attractive radionuclide for various therapeutic applications. Ethylene diamine tatramethylene phosphonate (EDTMP) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. Materials and Methods: Enriched 176Lu2O3 was dissolve...

Akbar Anvari Ali Bahrami-Samani, Amir Reza Jalilian Hassan Yousefnia Mahmoud Reza Aghamiri Mohammad Ghannadi-Maragheh Simindokht Shirvani-Arani

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

Ali Bahrami-Samani Amir Reza Jalilian, Moein Meftahi Mohammad Ghannadi-Maragheh Sedigheh Moradkhani Simindokht Shirvani-Arani,

  Introduction: Nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. Among those, 153Sm-ethylenediamine tetramethylene phosphonic acid (153Sm-EDTMP) is the major therapeutic agent which is widely used in the world. In this study, production, quality control and biodistribution studies of this therapeut...

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