Following the 2010 cholera outbreak in Haiti, a plan was initiated to provide massive improvements to the sanitation and drinking water infrastructure in order to eliminate cholera from the island of Hispaniola by 2023. Six years and a half billion dollars later, there is little evidence that any substantial improvements have been implemented; with increasing evidence that cholera has become en...

In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...

BACKGROUND There is evidence to suggest that antiretroviral therapy (ART) and testing for human immunodeficiency virus (HIV) reduce the probability of transmission of HIV. This has led health officials across the United States to take steps toward a test-and-treat policy. However, the extent of the benefits generated by test-and-treat is debatable, and there are concerns, such as increased mult...

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 2, Volume 15, 2023: The papers published in this issue represent interesting novelties different topics of life science. Among the exciting research or reviews, we invite readers to find news about: Neuroprotective role a protoberberine alkaloid against aluminum-induced neuroinflammation and excitotoxicity; Evaluation cross-ge...

This study describes the demographics and treatment status of HIV-infected adults accessing ambulatory care in the Republic of Ireland and estimates diagnosed HIV prevalence rates. 3254 HIV-infected adults attended 1 of the 6 specialist HIV centres in the 12- month period 1st July 2009 to 30th June 2010. 2023/3254 (62%) were male, 1761/3133 (56%) Irish and 1048/3133 (34%) African. 1924/3098 (62...

Improved aerospace surveillance and battlespace management (ASBM) is fundamental to the defence of Australia and its interests. DSTO has been asked to assist in the development a capability roadmap for ASBM, which can chart the course from the current systems to the capability required in 20 years time i.e. 2023. In order to do this we need to understand what the possibilities are for ASBM in 2...

Applications Submission date: July 31, 2002 Word count: 6633 + (3 figures) * 250 words/figure = 7383 Michael Mahut, INRO Consultants, Inc., 5160 Decarie Blvd. Suite 610, Montreal H3X 2H9, Canada. Telephone: (514) 369-2023; fax: (514) 369-2026; e-mail: [email protected] Michael Florian, University of Montreal, P.O. box 6120, station centre-ville, Montreal H3C 3J7, Canada; and INRO Consultants, In...