with estrogen-like activities. Isoflavones and lignans have been categorized as phytoestrogens, based on their chemical structures and activities. Phytoestrogens have been explored in the field of metabolic degradation by intestinal bacteria. In particular, the biotransformation of plant lignans, such as secoisolariciresinol diglucoside (SDG), pinoresinol diglucoside (PDG), arctiin, and mataire...

Purpose. Leber congenital amaurosis (LCA), a genetically and clinically heterogeneous disease, is the earliest onset retinitis pigmentosa (RP) and is the most severe of hereditary retinal dystrophies. This study was conducted to investigate genetic and clinical features of LCA in a set of Japanese male twins with LCA. Methods. To identify causative mutations, 74 genes known to cause RP or LCA w...

Australia has a unique and highly successful screening program for cervical cancer which is based on the conventional Pap smear. Since its introduction in 1991 there has been a decline in both the incidence of and mortality from this disease. Part of the success of this program has been the introduction of Pap test registers and strict quality assurance measures for cervical cytology, including...

Neighborhood matters: Response to EZH2 methyltransferase inhibitors Comment on: Amatangelo MD, et al. Cell Cycle 2013; 12:2113–9; PMID:23759589; http://dx.doi.org/10.4161/cc.25163 Kshipra M Gharpure and Anil K Sood*; Department of Gynecologic Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Center for RNA Interference and Non-Coding RNAs; The University of Texas MD ...

We study a block triangular preconditioner for finite element approximations of the linearized Navier–Stokes equations. The preconditioner is based on the augmented Lagrangian formulation of the problem and was introduced by the authors in [SIAM J. Sci. Comput., 28 (2006), pp. 2095–2113]. In this paper we prove field-of-values type estimates for the preconditioned system which lead to optimal c...