Background: MicroRNA (miR) dysregulation is found in Alzheimer's disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology. Results: miR-144 suppresses ADAM10 expression and is up-regulated by activator protein-1. Conclusion: miR-144 is negative regulator of ADAM10 and may be involved in AD pathogenesis. Significance: The first w...

1. Manifolds: 1/7/14 1 2. Tangent and Cotangent Spaces: 1/9/14 3 3. Vector Fields, One-Forms, and Riemannian Metrics: 1/14/14 6 4. The Lie Bracket and Riemannian Connections: 1/16/14 8 5. Existence and Uniqueness of the Riemannian Connection: 1/21/14 10 6. Tensor Fields, Parallel Transport, and Holonomy: 1/23/14 13 7. The Riemann Curvature Tensor: 1/28/14 15 8. Flatness: 1/30/14 17 9. Symmetrie...

Flexibility vs. Rigidity: Does Spain have the worst of both Worlds? In this paper we study the structure of labor market flows in Spain and compare them with France and the US. We characterize a number of empirical regularities and stylized facts. One striking result is that the job finding rate is slightly higher than in France, while the jon loss rate is much higher, putting Spain half-way be...