G. Kiriakidis 1,2 , I. Kortidis , K. Moschovis 1,2 I. Institute of Electronic Structure and Laser, FORTH, P.O. Box 1527, Vassilika Vouton, 711 10 Heraklion, Crete, Greece. University of Crete, Physics Department, 710 03 Heraklion, Crete, Greece. Center of Materials Technology and Laser, School of Applied Technology, Technological Educational Institute of Crete, 710 04 Heraklion, Crete, Greece. ...

predictors of hemodynamic improvement after pulmonary thromboendarterectomy. Chest 2005; 127: 1606–1613. 6 Mayer E, Jenkins D, Lindner J, et al. Surgical management and outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry. J Thorac Cardiovasc Surg 2011; 141: 702–710. 7 Condliffe R, Kiely DG, Gibbs JS, et al. Prognostic and ae...

BACKGROUND Parathyroid hormone-related protein (PTHrP) has anabolic effects in bone, which has led to the clinical use of N-terminal fragments of PTHrP and PTH. Since 10% to 20% of fractures demonstrate healing complications and osteoporosis continues to be a debilitating disease, the development of bone-forming agents is of utmost importance. Due to evidence that regions of PTHrP other than th...

Ticlopidine is a first-generation thienopyridine antiplatelet drug that prevents adenosine 59-diphosphate (ADP)-induced platelet aggregation. We identified the enzymes responsible for the two-step metabolic bioactivation of ticlopidine in human liver microsomes and plasma. Formation of 2-oxo-ticlopidine, an intermediate metabolite, was NADPH dependent and cytochrome P450 (CYP) 1A2, 2B6, 2C19, a...

A four year-old-girl with Diamond-Blackfan anemia (DBA) that was resistant to corticosteroid treatment and transfusion dependent underwent (bone marrow transplantation) BMT from HLA identical sibling. The patient was conditioned with busulfan and cyclophosphamide and achieved complete marrow engraftment and mixed chimerism in DNA analysis. For the following 13 months she was not transfusion dep...

0 Testing means 0.1 known population mean and variance Consider the following scenario: The population of a small town was unknowingly exposed to an environmental toxin over the course of several years. There is a possibility that exposure to the toxin during pregnancy adversely affects cognitive development which eventually leads to lower verbal IQ. To determine if this has happened to the chi...

Full-length human parathyroid hormone-related protein (PTHrP-(1-141] as well as a carboxyl-terminal shortened form (PTHrP-(1-108] have been expressed from recombinant DNA-derived clones. These proteins were expressed in Escherichia coli as fusion proteins so that cyanogen bromide cleavage yields the desired product. Both proteins were purified and then characterized by sodium dodecyl sulfate ge...

Abstract Background Pregnant women with inflammatory bowel diseases (IBD) are prone to adverse pregnancy outcomes. This study aimed assess outcomes and disease management for pregnant patients IBD treated at a multi-disciplinary IBD- maternal-fetal medicine (MFM) clinic. Methods retrospective cohort included consecutive having singleton gestation who attended the IBD-MFM clinic Rabin Medical Ce...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been defined as major environmental pollutants. While previous studies have found that PBDEs may enhance the levels of sex-steroid hormones, their effects on testosterone secretion from rat Leydig cells are unclear. This study investigated the effects and mechanisms of PBDE-710, a mixture of tetra- and p...