Von Liebig noted in his most famous book that agriculture’s principal objective is the production of digestible N (1). This task was particularly challenging in all traditional (pre-industrial) agricultures. They had 3 ways in which to provide N for crops: i) recycling of organic wastes (mainly crop residues and animal and human wastes); ii) crop rotations including N-fixing leguminous species;...

Accidental hypothermia is generally manifested as progression from an initial state of catecholamine release and stimulation (mild hypothermia) to one marked by a predictable slowing of metabolism and all critical body functions to the extent that patients may appear dead. The profound physiologic changes and metabolic slowing all reverse with rapid rewarming, and reports of remarkable neurolog...

Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti-CD154 improves survival. The CD154-specific Ab IDEC-131 was tested alone and in combination with rapamycin for its ability to inhibit rhesus MLRs. The ability of the Ab to block endothelial activation was also assessed. ...

OBJECTIVE The current study aimed to determine the efficacy of radioiodine-131 ((131)I) ablation therapy with thyroid hormone replacement one day before (131)I administration in patients with well-differentiated thyroid cancer (DTC). METHODS This retrospective study included 29 patients who underwent (131)I therapies twice for DTC during 6-12 months. Since all the patients obviously had resid...

The aim of the present study was to evaluate the role of selenium (Se) on the thyroid uptake and retention of radioiodine ((131)I) and on the serum levels of thyroid hormones. Experimental rats were divided into four groups with 10 animals in each group viz: untreated controls, (131)II-treated, Se-treated and (131)I+Se-treated. Group II and Group IV animals were injected intraperitoneally with ...

Despite extensive use of iodine-131 ((131)I) treatment for Graves' hyperthyroidism, the optimal regimen of pretreatment with antithyroid drugs is still a matter of discussion. Our aim was to evaluate the success of (131)I treatment in patients with Graves' disease without and with pretreatment with methimazole (MMI). In a prospective randomized study 156 patients with Graves' disease were treat...

Background. The most appropriate therapy for papillary microcarcinoma (PMC) is controversial. Methods. We reviewed the therapy and outcome of 407 patients with PMC. Results. Three hundred-eighty patients underwent total thyroidectomy, and 349 patients received I-131 therapy. The median followup was 5.3 years. Forty patients developed recurrent disease. On univariate analysis, development of dis...

BACKGROUND Finding a specific agent is useful for early detection of tumor. Angiotensin II type 1 receptor (AT1R) was reported to be elevated in a variety of tumors and participate in tumor progression. The aim of our study was to evaluate whether (131)I-anti-AT1R monoclonal antibody (mAb) is an efficient imaging reporter for the detection of hepatocellular carcinoma. METHODOLOGY/PRINCIPAL FI...