INTRODUCTION We determined the contribution of the methylene tetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C gene polymorphisms to the susceptibility to rheumatoid arthritis (RA). We also assessed whether these two MTHFR gene polymorphisms may be implicated in the development of cardiovascular (CV) events and subclinical atherosclerosis manifested by the presence of endothelial dysfunct...

We assessed the effect of a recently described mutation in the MTHFR gene (1298 A --> C) on the risk of deep venous thrombosis (DVT) by determining its prevalence in 190 patients with verified DVT and in age-, race- and gender-matched controls. MTHFR 1298 A --> C was found in 42.1% of patients and in 41.1% of controls. The OR for venous thrombosis was 1.07 (95% CI 0.70-1.65) for heterozygotes a...

Introduction. Knowledge of the mechanism of action of probiotics in subjects with irritable bowel syndrome (IBS) is imperfect. Objective. This trial aimed at discriminating between a direct effect on the gut wall and an indirect effect caused by modulation of the fecal microbiota. Design. Randomized, double-blind, crossover trial. Material and Methods. Patients with IBS were given one capsule o...

Time Topic Speaker 1600 1645 Anesthesia for the Patient with Severe Lung Disease Peter Slinger, MD 1645 1730 I Can't See!: Post-Operative Vision Loss Clint Christensen, MD 1730 1740 Break 1740 1825 When Time is Brain: Emergency Neurologic Life Support for Anesthesiologists Doro Rosenberger, MD 1825 1900 Questions and Answers Panel continued.... University of Utah Anesthesiology Department's 61s...

[This retracts the article on p. 1298 in vol. 7, PMID: 27656152.].

word count = 250 Manuscript word count = 1825 Running Head: Validation of prostate-volume-based decision rules

Cytochrome P450 (P450) 2C9 is an important member of the P450 enzyme superfamily, with 58 CYP2C9 allelic variants previously reported. Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. The aim of this study was to assess the catalytic activities of 38 human CYP2C9 alleles, including 24 novel ...

objective: the aim of this in vitro study was to compare the coronal microleakage between streptococcus sanguis per se and a mixture suspension of e. faecalis and c. albicans in root canals filled with gutta-percha and either ah 26 or ah plus sealer. materials and methods: one-hundred and ten extracted human teeth were decoronated to a standardized root length of 14 mm and prepared using mtwo n...