With the assistance of molecular docking and 3D-QSAR models established previously, structurally identical (18)F- and (125)I-labeled benzyloxybenzene derivatives were designed to achieve the early detection of Aβ plaques by PET/SPECT imaging. In competition binding assay, ligands 7a and 12a displayed high binding affinities to Aβ42 aggregates with Ki values of 19.5 nM and 23.9 nM, respectively....

Background: Near infrared spectroscopy imaging is one of the new techniques used for investigating structural and functionality of different body tissues. This is done by injecting light into the medium and measuring the photon intensity at the surface of the tissue.Method: In this paper the different medical applications, various imaging and simulation techniques of NIRS imaging is described. ...

Introduction: All of the Imaging modalities have advantages and disadvantages alone. So if we want to have the best and perfect image, combining these modalities produces something we desired. PET-MR images consist of morphologic and metabolic data. MRI and PET provide high spatial and contrast resolution and high sensitivity and molecular information respectively. Hybrid PET-...

AbstractPurpose Several magnetic resonance imaging (MRI) techniques exploit the difference in susceptibilities between tissues, but systematic measurements of tissue susceptibility are lacking. Furthermore, there is question as to whether chemical fixation that used for ex vivo MRI studies, affects properties tissue. Here, we determined and water content fresh chemicall...

Introduction: Brachytherapy is one type of internal radiation therapy where radiation sources, which are usually encapsulated, are placed as close as possible to the tumor site or inside the patient's body. In this technique, it is important to determine dose distribution around the brachytherapy capsule to create optimal treatment plant. In this way, dosimetric parameters are...

Contact: [email protected] Fax: +81-78-306-3090 RIKEN Center for Developmental Biology Improved tissue clearing solution for super-resolution imaging April 7, 2016–As biologists seek to gain further insights on subcellular structures deeply embedded in various tissues, high resolution fluorescence microscopy using various fluorescent markers has emerged as a powerful tool to ‘see’ inside...

The G protein-coupled apelin receptor (APJ) binds the endogenous peptide apelin and has been shown to have roles in many physiological systems. Thus far, distribution studies have predominantly been conducted in the rat and there is limited knowledge of the cellular distribution of APJ in mouse or human tissues. As recent functional studies have been conducted in APJ knock-out mice (APJ KO), in...

Introduction: Electrical impedance tomography (EIT) is a non-invasive technique utilized in various medical applications, including brain imaging and other neurological diseases. Recognizing the physiological and anatomical characteristics of organs based on their electrical properties is one of the main applications of EIT, as each variety of tissue structure has its own electrical characteris...