UNLABELLED Increased expression of the sodium iodide symporter (NIS) is required for effective radioiodine treatment and reporter gene imaging of breast cancer. We investigated the effect of retinoic acid on adenovirus-mediated expression of the human NIS gene in the MCF-7 breast cancer cell line. METHODS The MCF-7 cell line was infected with recombinant adenovirus carrying the human NIS gene...

OBJECTIVES Pharmacokinetically enhanced co-amoxiclav 2000/125 mg was designed to achieve high serum concentrations of amoxicillin over the 12 h dosing interval to eradicate Streptococcus pneumoniae with amoxicillin MICs of at least 4 mg/L. METHODS This randomized, double-blind, double-dummy, multicentre study compared the efficacy and safety of oral co-amoxiclav 2000/125 mg twice daily versus...

AIM The prognosis of patients with ovarian cancer depends on stage, histological type, age, presence of ascites, performance status and debulking surgery. Complete cytoreductive surgery is the most important prognostic factor. We investigated the suitability of Ca 125 as a prognostic factor in patients with ovarian cancer at various. PATIENTS AND METHODS In a retrospective analysis, the Ca 12...

freezing injury is an important limiting factor in the production of pomegranate in iran.the aim of the present study was to evaluate the effect of paclobutrazol (pbz) on cold hardiness of pomegranate (punica granatum l.) cv. ‘malas saveh’. different concentrations of pbz including 0 (control), 31, 62, 125 or 250 mg l–1 were sprayed on one-year-old plants in august and the electrolyte leakage o...

BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor (alpha-FR)-overexpressing tumors. Affinity of BGC 945 for the alpha-FR is 70% of the high-affinity ligand folic acid. In contrast to conventional antifolates, BGC 945 has low affinity for the widely expressed reduced-folate carrier (RFC). The K(i) for isolated thymidyl...

Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial for determining cut-off values clinicopathological factors.
 Study design: 161 patients were included study. The inclusion criteria histopathological confirmation and with CA-125 levels measured at most ten days before surgery. association between value variable...

This article is part of a Minifocus on Ubiquitin. For further reading, please see related articles: ʻEmerging regulatory mechanisms in ubiquitin-dependent cell cycle controlʼ by Annamaria Mocciaro and Michael Rape (J. Cell Sci. 125, 255-263). ʻThe role of ubiquitylation in receptor endocytosis and endosomal sortingʼ by Kaisa Haglund and Ivan Dikic (J. Cell Sci. 125, 265-275). ʻCellular function...

In multiple myeloma, the presence of highly resistant cancer stem cells (CSC) that are responsible for tumor metastasis and relapse has been proven. Evidently, for achieving complete response, new therapeutic paradigms that effectively eradicate both, CSCs and bulk cancer populations, need to be developed. For achieving that goal, an innovative two-step treatment combining targeting of thymidin...

Pharmacokinetic (PK) and pharmacodynamic (PD) principles that predict antimicrobial efficacy can be used to set targets for antimicrobial design and optimisation. Although current formulations of amoxicillin and amoxicillin/clavulanate have retained their efficacy against many, but not all, penicillin-nonsusceptible Streptococcus pneumoniae, additional coverage is required to address the growin...

The formation of tissue iodoproteins during the peripheral metabolism of the thyroid hormones was examined by determining the concentration of nonethanol-extractable (125)I (NE(125)I) in various tissues after the intravenous injection of 3,5,3'-triiodo-L-thyronine (T3-(125)I) and L-thyroxine-(125)I (T4-(125)I) in groups of rats with iodide-blocked thyroid glands. 3 days after T3-(125)I and 7 da...