In the title compound, C(19)H(13)N(5)·C(4)H(8)O(2)·2H(2)O, the mol-ecular skeleton of the 2,6-bis-(benzimidazol-2-yl)pyridine (bbip) mol-ecule is essentially planar (r.m.s. deviation = 0.023 Å). An extensive three-dimensional network of inter-molecular N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds consolidates the crystal packing, which also exhibits π-π inter-actions between the five- and six-membered...

(a) y′ = 1 + xy (b) y′ = −2xy (c) y′ = 1− 2xy Answer: If (b) were correct, then, when x = 0, we would have that y′ = 0. However, the slope of the tangent line is clearly positive when x = 0 in the picture, so (b) cannot be correct. If (a) were correct, then y′ would be positive for all positive values of x. However, the slope of the tangent line is clearly negative for most positive x, so (a) c...

23 января 2022 г. исполнилось 115 лет со дня рождения выдающегося ученого Валентина Алексеевича Каргина. Каргин Валентин Алексеевич: академик АН СССР (1953), Герой Социалистического Труда, лауреат Ленинской и четырех Государственных премий, награжден тремя орденами Ленина, двумя Трудового Красного Знамени многими медалями, дважды премия имени А.Н. Баха, один из основоположников науки о полимера...

We studied the influence of acidosis on the positive inotropic effect of UD-CG 212 Cl (4,5-dihydro-6-[2-(4-hydroxyphenyl)-1H-benzimidazole-5-yl]-5-methyl-3(2H)-pyridazinone), an active metabolite of pimobendan, in canine ventricular trabeculae loaded with aequorin. The positive inotropic effect of UD-CG 212 Cl was markedly suppressed under acidotic conditions. The maximal contractile response t...