product code, the date and time of container closure inspections, the measurements obtained, and all corrective actions taken. Records shall be signed or initialed by the container closure inspector and reviewed by management with sufficient frequency to ensure that the containers are hermetically sealed. (d) Records shall be maintained to identify the initial distribution of the finished produ...

N-Methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]benzamide (axitinib) is an oral inhibitor of vascular endothelial growth factor receptors 1–3, which is approved for the treatment of advanced renal cell cancer. Human [C]-labeled clinical studies indicate axitinib’s primary route of clearance is metabolism. The aims of the in vitro experiments presented herein were to identify an...

changed in response to the fear of AIDS, focusing on the contraceptive behavior of single men and women. We also analyze recent trends in condom use that may have been influenced by increasing fear of sexually transmitted diseases (STDs), as well as by contraceptive needs. We distinguish the percentages of men and women who currently use condoms (at the time of the survey), who have ever used c...

High-resolution mass spectrometry (MS)-based proteomics is a powerful method for the identification of soluble protein complexes and large-scale affinity purification screens can decode entire protein interaction networks. In contrast, protein complexes residing on chromatin have been much more challenging, because they are difficult to purify and often of very low abundance. However, this is c...

The aim of this study was to investigate the relationship between visual evoked potentials (N1, P2, N2, P3 and Sw) and levels of neuroticism, psychoticism and depression. Based on previous research, longer EP-latencies were expected in more depressed subjects, and smaller EP-amplitudes in subjects with higher levels of neuroticism and psychoticism. The sample consisted of female psychology stud...

Darunavir (formerly TMC114) is a second-generation, sulfonamide-based, peptidomimetic protease inhibitor (PI) with a modified 3-dimensional structure enabling more efficient binding to HIV protease. It has become an important drug, in combination with low-dose ritonavir boosting, in the treatment of both antiretroviral-naïve and multiclass-experienced patients. Growing data now exist suggesting...