Copper-phenanthroline complexes oxidatively damage and cleave nucleic acids. Copper bis-phenanthroline and copper complexes of mono- and bis-phenanthroline conjugates are used as research tools for studying nucleic acid structure and binding interactions. The mechanism of DNA oxidation and cleavage by these complexes was examined using two copper-phenanthroline conjugates of the sequence-specif...

The title complex, [Mn(C(5)O(5))(C(12)H(8)N(2))(2)], lies across a crystallographic twofold axis which passes through the Mn atom and bisects the croconate ligand. The two 1,10-phenanthroline (phen) ligands are arranged in a propeller manner and the local mol-ecular geometry of the MnN(4)O(2) unit is severely distorted octa-hedral. This may be inter-preted as a structural perturbation of the Mn...

In the title polymer, [Cd(C(2)N(3))(2)(C(16)H(16)N(2)O(2))](n), the Cd(II) ion is coordinated by two N atoms from one 2,9-dieth-oxy-1,10-phenanthroline mol-ecule and four N atoms from four symmetry-related dicyanamide ions in a distorted octa-hedral geometry. In the 2,9-dieth-oxy-1,10-phenanthroline ligand, the O and C atoms of the eth-oxy groups are located almost in the plane defined by the p...

[Fe(1,10-phenanthroline)3] 2+ is known to racemise in solution and DNA is known to shift the equilibrium point of the /-[Fe(1,10-phenanthroline)3] 2+ mixture from 50:50 to a position favouring a slight excess of the  enantiomer. In this paper it is shown that DNA catalyses the racemisation reaction, presumably by providing vibrational energy to species that bind in a less favoured mode for t...

1. Yeast alcohol dehydrogenase (EC 1.1.1.1) is inhibited in the presence of 1,10-phenanthroline. 2. A conformational change in the enzyme's structure is induced by 1,10-phenanthroline, and is abolished in the presence of NADH. 1,10-Phenanthroline binds to the enzyme competitively with respect to NADH, with a stoicheiometry of 2 mol of 1,10-phenanthroline/144000g of enzyme. 3. 1,10-Phenanthrolin...

The present study describes the antioxidant activity of 1,10-phenanthroline, 5-amino-1,10-phenanthroline and their Pd complexes: Pd(5-NH2-phen)2(NO3)2 and Pd(phen)2(NO3)2(H2O). It is evaluated in situ using HORAC (Hydroxyl Radical Averting Capacity) and ORAC (Oxygen Radical Absorbance Capacity) methods. The best antioxidant activity determined by HORAC method refers to Pd(5-NH2-phen)2(NO3)2. It...

Abstract The unfolded protein response has recently been implicated as a mechanism by which 1,10-phenanthroline-containing coordination compounds trigger cell death. We explored the interaction of two such compounds—one containing copper and one manganese—with endoplasmic reticulum (ER) stress. Pretreatment with anisomycin significantly enhanced cytotoxic activity both metal-based in A2780, but...

A caged rhodamine 110 derivative for the specific labeling of SNAP-tag fusion proteins is introduced. The caged rhodamine 110 derivative permits the labeling of cell surface proteins in living cells and of intracellular proteins in fixed cells. The probe requires only a single caging group to maintain the fluorophore in a non-fluorescent state and becomes highly fluorescent after uncaging. The ...

The requirement for Zn(++) in DNA replication by phytohemagglutinin-stimulated human lymphocytes was studied. When 6 microM o-phenanthroline, a chelator with a high affinity for Zn(++), is added to cultures of stimulated lymphocytes a nearly complete inhibition of thymidine incorporation results within a few hours. In contrast, the incorporation of uridine is only slightly reduced and the incor...

In the title compound, C29H19F3N2O, a phenanthroline-fused imidazole tetra-cyclic system, the fused benzene rings deviate slightly from the central ring and make dihedral angles with this ring of 3.47 (8) and 3.05 (8)°. The tri-fluoro-methyl-phenyl ring is roughly coplanar with the phenanthroline-fused imidazole tetra-cyclic system [dihedral angle = 11.02 (6)°], while the meth-oxy-phenyl ring i...