The Human Genome Initiative has increased significantly the rate at which disease-causing genes are being mapped and sequenced. New cost-effective methods to locate the genes and to characterize disease-causing mutations require robust, reproducible, and accurate protocols for measuring DNA fragment lengths. Capillary array electrophoresis (CAE) offers rapid, high-resolution separations, high t...

The Human Genome Initiative has increased significantly the rate at which disease-causing genes are being mapped and sequenced. New cost-effective methods to locate the genes and to characterize disease-causing mutations require robust, reproducible, and accurate protocols for measuring DNA fragment lengths. Capillary array electrophoresis (CAE) offers rapid, high-resolution separations, high t...

This paper presents a Class-D power amplifier for bandpass pulse width modulated (BP-PWM) and bandpass deltasigma modulated (BP-DSM) signals at 20 MHz. A 1-bit 6-th order topology is used in the ∆Σ-modulator. Integral noise shaping is used in the generation of the bandpass pulse width modulated signal. A two sided pulse width modulation is used with a 6-bit 4th-order noise shaper. The push-pull...

Two Amerindian demographic shifts are attributed to climate change in the northwest plains of North America: at approximately 11,000 calendar years before present (yr BP), Amerindian culture apparently split into foothills-mountains vs. plains biomes; and from 8,000-5,000 yr BP, scarce archaeological sites on the open plains suggest emigration during xeric "Altithermal" conditions. We reconstru...

We find new facet-defining inequalities for the linear ordering polytope generalizing the well-known Möbius ladder inequalities. Our starting point is to observe that the natural derivation of the Möbius ladder inequalities as {0, 1 2 }-cuts produces triangulations of the Möbius band and of the corresponding (closed) surface, the projective plane. In that sense, Möbius ladder inequalities have ...

Kinship testing of a father and his son from Guangxi, China, the location of the Zhuang minority people, was performed using the PowerPlex® 18D System with a short tandem repeat typing kit. The results indicated that both the father and his son had an off-ladder allele at the Penta D locus, with a genetic size larger than that of the maximal standard allelic ladder. To further identify this loc...

Deteksi patogen penyebab penyakit tumbuhan dapat dilakukan baik secara langsung maupun tidak langsung. umumnya dengan menggunakan metode serologi dan molekuler. bakteri teknik molekuler polymerase chain reaction (PCR). Penyakit hawar malai yang disebabkan oleh Burkholderia glumae dilaporkan telah menginfeksi tanaman padi di Indonesia. B. terbawa benih sehingga berpotensi menyebar cepat. Penelit...

We present a rapidly fabricated micro-capillary electrophoresis chip that utilizes surface-tension-driven flow for sample injection and extraction of DNA. Surface-tension-driven flow (i.e. passive pumping) [G. M. Walker et al., Lab. Chip. 2002, 2, 131-134] injects a fixed volume of sample that can be predicted mathematically. Passive pumping eliminates the need for tubing, valves, syringe pumps...

A unique mRNA produced by the t(15;17)(q22-24;qll21) translocation in the leukemic cells of acute promyelocytic leukemia patients encodes a chimeric protein, PML/ RARa, which is formed by the fusion of the retinoic acid receptor a (RARa) and the promyelocytic locus gene (PML). This translocation is often the only visible karyotypic aberration present which is detected in almost 100% of acute pr...