OBJECTIVE Hyaluronan (HA) is an important extracellular matrix component and is involved in fluid homeostasis, tissue repair, and response to infections. Previous studies have shown that supplementation of dialysis fluid with high molecular weight HA may have a positive impact on peritoneal solute and fluid transport characteristics. In the present study, we investigated the impact of HA on the...

Materials Sodium form of hyaluronic acid (HA, MW, 10 kDa) was a gift of Kolon Life Science, Korea. EDC.HCl (99%) and N-Hydroxy succinimide (NHS, 99%) were purchased from Shanghai Medeep Co., Ltd. Monostearin (glycerol α-monostearate, GMS), Sodium deoxycholate (DOC) and fluorescein isothiocyanate (FITC) were purchased from Solarbio (Beijing, China). Doxorubicin hydrochloride (DOX) was supplied b...

Binding of hippuric acid (HA), a uremic toxin, with human serum albumin (HSA) has been examined by isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), molecular docking, circular dichroism (CD) and fluorescence spectroscopy to understand the reason that govern its impaired elimination through hemodialysis. ITC results shows that the HA binds with HSA at high (K b ~1...

Taxus baccata is a native species to the Caspian forests and is considered as the identification of these forests by some resources. The aim of this study was to understand the ecological characteristics of T. baccata in order to find suitable areas for its plantation in the Pone Aram preserve of Golestan province. Therefore, Multi-Criteria Evaluation (MCE) methods based on Analytical Hierarchy...

Local induction of pro-tolerogenic cytokines, such as IL-10, is an appealing strategy to help facilitate transplantation of islets and other tissues. Here, we describe a pair of implantable devices that capitalize on our recent finding that hyaluronan (HA) promotes IL-10 production by activated T cells. The first device is an injectable hydrogel made of crosslinked HA and heparan sulfate loaded...

Context Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, sugges...

CONTEXT Polycystic ovary syndrome (PCOS) is a triad of anovulation, insulin resistance, and hyperandrogenism. Androgen excess may correlate with metabolic risk and PCOS consensus criteria define androgen excess on the basis of serum T. Here we studied the utility of the androgen precursor serum androstenedione (A) in conjunction with serum T for predicting metabolic dysfunction in PCOS. PATIE...

The polymorphic minor histocompatibility Ag HA-1 locus encodes two peptides, HA-1(H) and HA-1(R), with a single amino acid difference. Whereas the immunogenicity of the HA-1(R) allele has not yet been shown, the nonameric HA-1(H) peptide induces HLA-A2-restricted cytotoxic T cells in vivo and in vitro. It is not known whether the mHag HA-1(H) or HA-1(R) associates with other HLA class I molecul...

A pronounced residual effect of organic and inorganic fertilizers, applied in maize crop was observed on yields of maize-gobhi sarson cropping system. The experiment was conducted with 10 treatments of N, P, K, FYM, crop residue and zinc sulphate nutrients. The highest growth, yield and yield components of maize crop were recorded with 100% recommended fertilizer dose-RFD + ZnSO4 20 kg/ha and t...