This study investigated the effects of garlic oil (0.25 g/L), nitrate (5 mM), and quillaja saponin (0.6 g/L), alone and in binary or ternary combinations, on methanogenesis, rumen fermentation, and abundances of select microbial populations using in vitro rumen cultures. Potential adaptation to these compounds was also examined by repeated transfers of the cultures on alternate days until day 1...

Glucose uptake by isolated diaphragms of both diabetic, following streptozotocin administration, and non-diabetic animals increased in presence of an oleanane-type triterpenoid saponin isolated from the roots of M. cymbalaria. Insulin release was augmented by the presence of the saponin of M. cymbalaria (1 mg/mL) in rat insulinoma cell line (RIN-5F) preexposed to adrenaline (5 microM) and nifed...

Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic ac...

WILKINS, A.L., MILES, C.O., DE KOCK, W.T., ERASMUS, G.L., BASSON, A.T. & KELLERMAN, T.S. 1996. Photosensitivity in South Africa. IX. Structure elucidation of a ~-glucosidase-treated saponin from Tribulus terrestris and the identification of saponin chemotypes of South African T. terrestris. Onderstepoort Journal of Veterinary Research, 63:327-334 Saponin C, a ~-glucosidase-treated saponin isola...

Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...

An experiment was conducted in vitro to determine whether the addition of saponin-containing Yucca schidigera or Quillaja saponaria reduces methane production without impairing ruminal fermentation or fiber digestion. A slightly lower dose of saponin was then fed to lactating dairy cows to evaluate effects on ruminal fermentation, methane production, total-tract nutrient digestibility, and milk...

After exposure of rat myotube cultures to saponin, less than 1% of the cellular protein was found to remain associated with the tissue culture substrate. This substrate-associated material contained approximately 10% of the acetylcholine receptors (AChRs) and greater than 80% of the large, ventral AChR clusters present in the original culture. The domain structure evident in intact cells was ma...

Two natural saponins 1 and 2, isolated from Solanum indicum L., and containing 2,3-branched sugar moieties, have been efficiently synthesized. Partially protected monosaccharide and disaccharide donors were used to facilitate target synthesis. Stereo factors were critical in incorporating 2,3-branched sugars on steroid aglycones. Saponin 1 was synthesized in five steps and 30% overall yield, wh...

The purpose of the present study has been to determine the change in the resistance of corpuscles to saponin with changes in pII., the acids employed being the common inorganic acids. Ponder (1) has shown that the rate of saponin hemolysis is increased in the presence of certain acids and has applied the equation Cl = R (C, + g) to systems in which an acid is the accelerating agent. Details of ...