Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastrointestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selecti...

In this paper, we report the reaction of isoamyl alcohol and 1-chloro-4-nitrobenzene was carried out in a batch reactor under aqueous-organic biphasic conditions using the techniques like phase transfer catalysis and ultrasound irradiation. Tetrabutylammonium bromide (TBAB) was employed as the phase transfer catalyst. The reaction is greatly enhanced by adding a small quantity of phase-transfer...

Changes in molecular forms of hepatic cytosolic glutathione S-transferases (GST) during rat chemical hepatocarcinogenesis were investigated. GST activities toward 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene increased with the increased area of gamma-glutamyltranspeptidase-positive foci and hyperplastic nodules induced by diethylnitrosamine followed by 2-acetylaminofluorene plus ...

An efficient solvent free reaction of 1-chloro-2-nitrobenzene with anilines to give N-substituted nitro anilines by nucleophilic aromatic substitution in good to excellent yields has been described. The effect of different salts on the reaction has also been studied.

In this study adsorption of 1-chloro-4-nitrobenzene (CNB) from aqueous solutions onto multi-walled carbon nanotubes (MWCNTs) was surveyed. The effect of some key parameters such as pH (2-10), carbon nanotubes dosage (0.02-0.1 mg/250mL), CNB concentration (2- 16 mg/L), and temperature (20,30,40,50°C) were investigated. The results showed that, the variation of initial pH and CNB concentration ex...

In this study adsorption of 1-chloro-4-nitrobenzene (CNB) from aqueous solutions onto multi-walled carbon nanotubes (MWCNTs) was surveyed. The effect of some key parameters such as pH (2-10), carbon nanotubes dosage (0.02-0.1 mg/250mL), CNB concentration (2- 16 mg/L), and temperature (20,30,40,50°C) were investigated. The results showed that, the variation of initial pH and CNB concentration ex...