Background: The events that trigger type 2 immune responses are not well characterized. Given the central role of sweat in maintaining skin hydration, sweating disturbance at points allergen entry would predispose to food sensitization. A previous study demonstrated epicutaneously applied hapten more readily penetrates stratum corneum with a lower water content than higher water. Thus, is likel...

INTRODUCTION Congenital myopathies (CM) often affect contractile proteins of the sarcomere, which could render patients susceptible to exercise-induced muscle damage. We investigated if exercise is safe and beneficial in patients with CM. METHODS Patients exercised on a stationary bike for 30 minutes, three times weekly, for 10 weeks at 70% of their maximal oxygen uptake (VO2max). Creatine ki...

PG 2131+066 is a composite–spectrum binary with a hot pulsating PG 1159-type pre–white dwarf and an early M-type main sequence star. Analysis of Whole Earth Telescope observations of the pulsating pre-white dwarf component provided an asteroseismological determination of its mass, luminosity, and effective temperature. These determinations allowed Kawaler et al. (1995) to determine the distance...

This paper provides a comprehensive examination of differences between relationship bank behavior for a set of borrowers that either underwent distress or filed for bankruptcy relative to normal times. Prior to distress, banks offer preferential contract terms in the form of lower interest rates and less collateral requirement to their relationship borrowers. After the onset of distress, banks ...

The activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) is dysregulated in a number of hematological and solid malignancies. Development of pharmacological STAT3 Src homology 2 (SH2) domain interaction inhibitors holds great promise for cancer therapy, and a novel class of salicylic acid-based STAT3 dimerization inhibitors that includes orally bioavai...