1 Sustainability Governance Project, Creative Research Initiative, Hokkaido University, N9W8, Kita-ku, Sapporo, Hokkaido 060-0809, Japan 2 Graduate School of Environmental Earth Science, Hokkaido University, N10W5, Kita-ku, Sapporo, Hokkaido 060-0810, Japan 3 Frontier Research System for Global Change, 3173-25 Showa-machi, Kanazawa-ku, Yokohama, Kanagawa 236-0001, Japan Received: 13 November 20...

Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan Department of Surgical Pathology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan Correspondence to: Satoru Kase. Department of Ophthalmology, Faculty of Medicine and Graduate School of Med...

Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-kinase Type III and Regulates Viral Propagation Yun-Sook Lim and Soon B. Hwang* From the National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, 431-060, Korea Running head: HCV NS5A modulates PI4KIII * Address correspondence to: Soon B. Hwang, Ph.D. Ilsong Institute o...

Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060, Japan, School of Chemistry, University of Tasmania, GPO Box 252-75, Hobart 7001, Australia, Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060, Japan, National Industrial Research Institute of Nagoya, 1-1 Hirate-cho, Kita-ku, Nagoya 462-8510, Japan, Au...

The clinical efficacy of anti-angiogenic therapies has been difficult to predict, and biomarkers that can predict responsiveness are sorely needed in this era of personalized medicine. CVX-060 is an angiopoietin-2 (Ang2) targeting therapeutic, consisting of two peptides that bind Ang2 with high affinity and specificity, covalently fused to a scaffold antibody. In order to optimize the use of th...

We investigated the mode of the 5-HT3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives, YM060, YM114 (KAE-393), YM-26103-2 and YM-26308-2, against 5-HT-induced transient bradycardia in anesthetized rats. Results were compared with those of ondansetron and granisetron. YM060 (0.03-0.1 microgram/kg, i.v.), YM114 (0.03-0.3 microgram/kg, i.v.), YM-26103-2 (0.01-0.03 microgram/kg, ...

1Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-ku, Sapporo 060-8556, Japan 2Department of Respiratory Medicine, Teine Keijinkai Hospital, 1-40, Maeda 1-12, Teine-ku, Sapporo 006-8555, Japan *Corresponding author Masanori Shiratori, MD Associate Professor Department of Respiratory Medicine and Allergology Sapporo Medical ...

High-precision Hylleraas-configuration-interaction Hy-CI method variational calculations are reported for the 2 S ground state of neutral lithium. The nonrelativistic energy is calculated to be −7.478 060 323 451 9 hartree, demonstrating that the Hy-CI technique is capable of sub-nanohartree accuracy for three-electron systems. A Hylleraas expansion without linked products of odd powers of rij ...

Nancy Berthier, Carlos Belmonte, Álvaro A. Fernández. (coords.)(2021). Filmar la ciudad. Guadalajara: Editorial Universidad de Guadalajara. 336 páginas. ISBN: 978-607-571-060-0

Purpose: This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated fully human monoclonal antibody that binds to human CD30, and to determine whether it exhibits greater in vitro and in vivo activity than its parental antibody. Experimental Design: Assaysmeasuring antibody binding to CD30-expressing cells and FcγRIIIa (CD16) transfectants as well as antibody-dependent cell...